BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration

Abstract BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients. This study aimed to analyze the relationship between the expression level of BIRC5 in different tumors and patient p...

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Autores principales:	Linlong Xu, Wenpeng Yu, Han Xiao, Kang Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/293877327c23491a87f7bdcf33f40745
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spelling	oai:doaj.org-article:293877327c23491a87f7bdcf33f407452021-12-02T14:12:10ZBIRC5 is a prognostic biomarker associated with tumor immune cell infiltration10.1038/s41598-020-79736-72045-2322https://doaj.org/article/293877327c23491a87f7bdcf33f407452021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79736-7https://doaj.org/toc/2045-2322Abstract BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients. This study aimed to analyze the relationship between the expression level of BIRC5 in different tumors and patient prognosis, clinical parameters, and its role in tumor immunity. Genes co-expressed with BIRC5 were analyzed, and functional enrichment analysis was performed. The relationship between BIRC5 expression and the immune and stromal scores of tumors in pan-cancer patients and the infiltration level of 22 tumor-infiltrating lymphocytes (TILs) was analyzed. The correlation of BIRC5 with immune checkpoints was conducted. Functional enrichment analysis showed that genes co-expressed with BIRC5 were significantly associated with the mitotic cell cycle, APC/C-mediated degradation of cell cycle proteins, mitotic metaphase, and anaphase pathways. Besides, the high expression of BIRC5 was significantly correlated with the expression levels of various DNA methyltransferases, indicating that BIRC5 regulates DNA methylation. We also found that BIRC5 was significantly correlated with multiple immune cells infiltrates in a variety of tumors. This study lays the foundation for future research on how BIRC5 modulates tumor immune cells, which may lead to the development of more effective targeted tumor immunotherapies.Linlong XuWenpeng YuHan XiaoKang LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linlong Xu Wenpeng Yu Han Xiao Kang Lin BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
description	Abstract BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients. This study aimed to analyze the relationship between the expression level of BIRC5 in different tumors and patient prognosis, clinical parameters, and its role in tumor immunity. Genes co-expressed with BIRC5 were analyzed, and functional enrichment analysis was performed. The relationship between BIRC5 expression and the immune and stromal scores of tumors in pan-cancer patients and the infiltration level of 22 tumor-infiltrating lymphocytes (TILs) was analyzed. The correlation of BIRC5 with immune checkpoints was conducted. Functional enrichment analysis showed that genes co-expressed with BIRC5 were significantly associated with the mitotic cell cycle, APC/C-mediated degradation of cell cycle proteins, mitotic metaphase, and anaphase pathways. Besides, the high expression of BIRC5 was significantly correlated with the expression levels of various DNA methyltransferases, indicating that BIRC5 regulates DNA methylation. We also found that BIRC5 was significantly correlated with multiple immune cells infiltrates in a variety of tumors. This study lays the foundation for future research on how BIRC5 modulates tumor immune cells, which may lead to the development of more effective targeted tumor immunotherapies.
format	article
author	Linlong Xu Wenpeng Yu Han Xiao Kang Lin
author_facet	Linlong Xu Wenpeng Yu Han Xiao Kang Lin
author_sort	Linlong Xu
title	BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
title_short	BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
title_full	BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
title_fullStr	BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
title_full_unstemmed	BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
title_sort	birc5 is a prognostic biomarker associated with tumor immune cell infiltration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/293877327c23491a87f7bdcf33f40745
work_keys_str_mv	AT linlongxu birc5isaprognosticbiomarkerassociatedwithtumorimmunecellinfiltration AT wenpengyu birc5isaprognosticbiomarkerassociatedwithtumorimmunecellinfiltration AT hanxiao birc5isaprognosticbiomarkerassociatedwithtumorimmunecellinfiltration AT kanglin birc5isaprognosticbiomarkerassociatedwithtumorimmunecellinfiltration
_version_	1718391775574360064

BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration

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