PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Loss-of-function mutations in an enzyme of unknown function, PNPLA1, cause dry and scaling skin in humans. Here Ohnoet al. show that PNPLA1 is a transacylase that acts in the final step of acylceramide production- esterification between ω-hydroxyceramide and linoleic acid acylceramide, yielding a li...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yusuke Ohno, Nozomi Kamiyama, Shota Nakamichi, Akio Kihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29388e6c378f489aaa22f8efa70254cf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:29388e6c378f489aaa22f8efa70254cf
record_format	dspace
spelling	oai:doaj.org-article:29388e6c378f489aaa22f8efa70254cf2021-12-02T14:40:25ZPNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide10.1038/ncomms146102041-1723https://doaj.org/article/29388e6c378f489aaa22f8efa70254cf2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14610https://doaj.org/toc/2041-1723Loss-of-function mutations in an enzyme of unknown function, PNPLA1, cause dry and scaling skin in humans. Here Ohnoet al. show that PNPLA1 is a transacylase that acts in the final step of acylceramide production- esterification between ω-hydroxyceramide and linoleic acid acylceramide, yielding a lipid essential for skin barrier function.Yusuke OhnoNozomi KamiyamaShota NakamichiAkio KiharaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Ohno Nozomi Kamiyama Shota Nakamichi Akio Kihara PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
description	Loss-of-function mutations in an enzyme of unknown function, PNPLA1, cause dry and scaling skin in humans. Here Ohnoet al. show that PNPLA1 is a transacylase that acts in the final step of acylceramide production- esterification between ω-hydroxyceramide and linoleic acid acylceramide, yielding a lipid essential for skin barrier function.
format	article
author	Yusuke Ohno Nozomi Kamiyama Shota Nakamichi Akio Kihara
author_facet	Yusuke Ohno Nozomi Kamiyama Shota Nakamichi Akio Kihara
author_sort	Yusuke Ohno
title	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
title_short	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
title_full	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
title_fullStr	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
title_full_unstemmed	PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
title_sort	pnpla1 is a transacylase essential for the generation of the skin barrier lipid ω-o-acylceramide
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29388e6c378f489aaa22f8efa70254cf
work_keys_str_mv	AT yusukeohno pnpla1isatransacylaseessentialforthegenerationoftheskinbarrierlipidōoacylceramide AT nozomikamiyama pnpla1isatransacylaseessentialforthegenerationoftheskinbarrierlipidōoacylceramide AT shotanakamichi pnpla1isatransacylaseessentialforthegenerationoftheskinbarrierlipidōoacylceramide AT akiokihara pnpla1isatransacylaseessentialforthegenerationoftheskinbarrierlipidōoacylceramide
_version_	1718390285409452032

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Ejemplares similares