p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and inv...

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Autores principales:	Talha Anwar, Caroline Arellano-Garcia, James Ropa, Yu-Chih Chen, Hong Sun Kim, Euisik Yoon, Sierrah Grigsby, Venkatesha Basrur, Alexey I. Nesvizhskii, Andrew Muntean, Maria E. Gonzalez, Kelley M. Kidwell, Zaneta Nikolovska-Coleska, Celina G. Kleer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581
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spelling	oai:doaj.org-article:293a4b7d30a541e885aa00f3154a95812021-12-02T14:39:24Zp38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis10.1038/s41467-018-05078-82041-1723https://doaj.org/article/293a4b7d30a541e885aa00f3154a95812018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05078-8https://doaj.org/toc/2041-1723Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion.Talha AnwarCaroline Arellano-GarciaJames RopaYu-Chih ChenHong Sun KimEuisik YoonSierrah GrigsbyVenkatesha BasrurAlexey I. NesvizhskiiAndrew MunteanMaria E. GonzalezKelley M. KidwellZaneta Nikolovska-ColeskaCelina G. KleerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Talha Anwar Caroline Arellano-Garcia James Ropa Yu-Chih Chen Hong Sun Kim Euisik Yoon Sierrah Grigsby Venkatesha Basrur Alexey I. Nesvizhskii Andrew Muntean Maria E. Gonzalez Kelley M. Kidwell Zaneta Nikolovska-Coleska Celina G. Kleer p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
description	Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion.
format	article
author	Talha Anwar Caroline Arellano-Garcia James Ropa Yu-Chih Chen Hong Sun Kim Euisik Yoon Sierrah Grigsby Venkatesha Basrur Alexey I. Nesvizhskii Andrew Muntean Maria E. Gonzalez Kelley M. Kidwell Zaneta Nikolovska-Coleska Celina G. Kleer
author_facet	Talha Anwar Caroline Arellano-Garcia James Ropa Yu-Chih Chen Hong Sun Kim Euisik Yoon Sierrah Grigsby Venkatesha Basrur Alexey I. Nesvizhskii Andrew Muntean Maria E. Gonzalez Kelley M. Kidwell Zaneta Nikolovska-Coleska Celina G. Kleer
author_sort	Talha Anwar
title	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
title_short	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
title_full	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
title_fullStr	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
title_full_unstemmed	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
title_sort	p38-mediated phosphorylation at t367 induces ezh2 cytoplasmic localization to promote breast cancer metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581
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p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

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