Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors

The synthesis of 18F-labeled positron emission tomography (PET) tracers is difficult and typically requires anhydrous conditions. Here, the authors developed organophosphine precursors that allow for quick, high-yield synthesis of 18F-labeled probes in either organic solvents or aqueous media.

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Detalles Bibliográficos
Autores principales:	Huawei Hong, Lei Zhang, Fang Xie, Rongqiang Zhuang, Donglang Jiang, Huanhuan Liu, Jindian Li, Hongzhang Yang, Xianzhong Zhang, Liming Nie, Zijing Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2940e739082042f2afcd9dc839c78979
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spelling	oai:doaj.org-article:2940e739082042f2afcd9dc839c789792021-12-02T17:01:39ZRapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors10.1038/s41467-019-08953-02041-1723https://doaj.org/article/2940e739082042f2afcd9dc839c789792019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08953-0https://doaj.org/toc/2041-1723The synthesis of 18F-labeled positron emission tomography (PET) tracers is difficult and typically requires anhydrous conditions. Here, the authors developed organophosphine precursors that allow for quick, high-yield synthesis of 18F-labeled probes in either organic solvents or aqueous media.Huawei HongLei ZhangFang XieRongqiang ZhuangDonglang JiangHuanhuan LiuJindian LiHongzhang YangXianzhong ZhangLiming NieZijing LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huawei Hong Lei Zhang Fang Xie Rongqiang Zhuang Donglang Jiang Huanhuan Liu Jindian Li Hongzhang Yang Xianzhong Zhang Liming Nie Zijing Li Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
description	The synthesis of 18F-labeled positron emission tomography (PET) tracers is difficult and typically requires anhydrous conditions. Here, the authors developed organophosphine precursors that allow for quick, high-yield synthesis of 18F-labeled probes in either organic solvents or aqueous media.
format	article
author	Huawei Hong Lei Zhang Fang Xie Rongqiang Zhuang Donglang Jiang Huanhuan Liu Jindian Li Hongzhang Yang Xianzhong Zhang Liming Nie Zijing Li
author_facet	Huawei Hong Lei Zhang Fang Xie Rongqiang Zhuang Donglang Jiang Huanhuan Liu Jindian Li Hongzhang Yang Xianzhong Zhang Liming Nie Zijing Li
author_sort	Huawei Hong
title	Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
title_short	Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
title_full	Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
title_fullStr	Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
title_full_unstemmed	Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
title_sort	rapid one-step 18f-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2940e739082042f2afcd9dc839c78979
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Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors

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