Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors

The synthesis of 18F-labeled positron emission tomography (PET) tracers is difficult and typically requires anhydrous conditions. Here, the authors developed organophosphine precursors that allow for quick, high-yield synthesis of 18F-labeled probes in either organic solvents or aqueous media.

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Autores principales: Huawei Hong, Lei Zhang, Fang Xie, Rongqiang Zhuang, Donglang Jiang, Huanhuan Liu, Jindian Li, Hongzhang Yang, Xianzhong Zhang, Liming Nie, Zijing Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2940e739082042f2afcd9dc839c78979
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