Learning differentially shapes prefrontal and hippocampal activity during classical conditioning

The ability to use sensory cues to inform goal-directed actions is a critical component of behavior. To study how sounds guide anticipatory licking during classical conditioning, we employed high-density electrophysiological recordings from the hippocampal CA1 area and the prefrontal cortex (PFC) in...

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Autores principales:	Jan L Klee, Bryan C Souza, Francesco P Battaglia
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	conditioning sharp-wave ripples CA1 PFC electrophysiology reward Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/294192ec059b4c0f8293707b5d90080c
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id	oai:doaj.org-article:294192ec059b4c0f8293707b5d90080c
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spelling	oai:doaj.org-article:294192ec059b4c0f8293707b5d90080c2021-11-15T05:42:01ZLearning differentially shapes prefrontal and hippocampal activity during classical conditioning10.7554/eLife.654562050-084Xe65456https://doaj.org/article/294192ec059b4c0f8293707b5d90080c2021-10-01T00:00:00Zhttps://elifesciences.org/articles/65456https://doaj.org/toc/2050-084XThe ability to use sensory cues to inform goal-directed actions is a critical component of behavior. To study how sounds guide anticipatory licking during classical conditioning, we employed high-density electrophysiological recordings from the hippocampal CA1 area and the prefrontal cortex (PFC) in mice. CA1 and PFC neurons undergo distinct learning-dependent changes at the single-cell level and maintain representations of cue identity at the population level. In addition, reactivation of task-related neuronal assemblies during hippocampal awake Sharp-Wave Ripples (aSWRs) changed within individual sessions in CA1 and over the course of multiple sessions in PFC. Despite both areas being highly engaged and synchronized during the task, we found no evidence for coordinated single cell or assembly activity during conditioning trials or aSWR. Taken together, our findings support the notion that persistent firing and reactivation of task-related neural activity patterns in CA1 and PFC support learning during classical conditioning.Jan L KleeBryan C SouzaFrancesco P BattagliaeLife Sciences Publications Ltdarticleconditioningsharp-wave ripplesCA1PFCelectrophysiologyrewardMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	conditioning sharp-wave ripples CA1 PFC electrophysiology reward Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	conditioning sharp-wave ripples CA1 PFC electrophysiology reward Medicine R Science Q Biology (General) QH301-705.5 Jan L Klee Bryan C Souza Francesco P Battaglia Learning differentially shapes prefrontal and hippocampal activity during classical conditioning
description	The ability to use sensory cues to inform goal-directed actions is a critical component of behavior. To study how sounds guide anticipatory licking during classical conditioning, we employed high-density electrophysiological recordings from the hippocampal CA1 area and the prefrontal cortex (PFC) in mice. CA1 and PFC neurons undergo distinct learning-dependent changes at the single-cell level and maintain representations of cue identity at the population level. In addition, reactivation of task-related neuronal assemblies during hippocampal awake Sharp-Wave Ripples (aSWRs) changed within individual sessions in CA1 and over the course of multiple sessions in PFC. Despite both areas being highly engaged and synchronized during the task, we found no evidence for coordinated single cell or assembly activity during conditioning trials or aSWR. Taken together, our findings support the notion that persistent firing and reactivation of task-related neural activity patterns in CA1 and PFC support learning during classical conditioning.
format	article
author	Jan L Klee Bryan C Souza Francesco P Battaglia
author_facet	Jan L Klee Bryan C Souza Francesco P Battaglia
author_sort	Jan L Klee
title	Learning differentially shapes prefrontal and hippocampal activity during classical conditioning
title_short	Learning differentially shapes prefrontal and hippocampal activity during classical conditioning
title_full	Learning differentially shapes prefrontal and hippocampal activity during classical conditioning
title_fullStr	Learning differentially shapes prefrontal and hippocampal activity during classical conditioning
title_full_unstemmed	Learning differentially shapes prefrontal and hippocampal activity during classical conditioning
title_sort	learning differentially shapes prefrontal and hippocampal activity during classical conditioning
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/294192ec059b4c0f8293707b5d90080c
work_keys_str_mv	AT janlklee learningdifferentiallyshapesprefrontalandhippocampalactivityduringclassicalconditioning AT bryancsouza learningdifferentiallyshapesprefrontalandhippocampalactivityduringclassicalconditioning AT francescopbattaglia learningdifferentiallyshapesprefrontalandhippocampalactivityduringclassicalconditioning
_version_	1718428541642604544

Learning differentially shapes prefrontal and hippocampal activity during classical conditioning

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