Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates

Introduction: Identification of latent tuberculosis (TB) infection is important in kidney transplant candidates. Due to the absence of a gold standard, both tuberculin skin test (TST) and interferon-gamma release assays (IGRA) are used to screen patients. The aim of this study was to evaluate the ag...

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Autores principales:	Shiva Samavat, Sam Alahyari, Ali Sangian, Malihe Nasiri, Mohsen Nafar, Ahmad Firoozan, Fariba Samadian, Nooshin Dalili, Fatemeh Poorrezagholi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	interferon-gamma release tests kidney transplantation latent tuberculosis infection tuberculin skin test Medicine R
Acceso en línea:	https://doaj.org/article/29457a872aee4556bbedf642a4027ae1
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spelling	oai:doaj.org-article:29457a872aee4556bbedf642a4027ae12021-11-12T10:25:23ZAgreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates1735-19951735-713610.4103/jrms.JRMS_708_20https://doaj.org/article/29457a872aee4556bbedf642a4027ae12021-01-01T00:00:00Zhttp://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=88;epage=88;aulast=Samavathttps://doaj.org/toc/1735-1995https://doaj.org/toc/1735-7136Introduction: Identification of latent tuberculosis (TB) infection is important in kidney transplant candidates. Due to the absence of a gold standard, both tuberculin skin test (TST) and interferon-gamma release assays (IGRA) are used to screen patients. The aim of this study was to evaluate the agreement of these two tests in patients undergoing renal transplantation. Materials and Methods: Two hundred kidney transplant candidates at a referral center in 2014–2017 were included in this study. TST and Quantiferon-Gold (QFT-G) tests were performed for all patients before transplantation. In case of a positive result in any of the tests, patients were administered a 9-month prophylaxis treatment using isoniazid. Cohen's kappa coefficient (k) test was used to determine the agreement between the two tests. Results: The mean age of patients was 40.72 ± 18.33. Nine (4.5%) patients had positive TST and 16 (8%) had positive IGRA. Concordance of the two tests was evaluated as medium (κ = 0.44 and P < 0.001). No association was found between the underlying causes of renal failure and skin test positive or IGRA. The tests showed a poor agreement among diabetics, candidates of re-transplantation, and those who were on dialysis for longer than a year (κ < 0.20). Conclusion: TST or IGRA can be used to screen TB in kidney transplant candidates with a moderate agreement. However, we suggest using both TST and QFT-G in diabetics, re-transplant candidates, and those on dialysis for >1 year.Shiva SamavatSam AlahyariAli SangianMalihe NasiriMohsen NafarAhmad FiroozanFariba SamadianNooshin DaliliFatemeh PoorrezagholiWolters Kluwer Medknow Publicationsarticleinterferon-gamma release testskidney transplantationlatent tuberculosis infectiontuberculin skin testMedicineRENJournal of Research in Medical Sciences, Vol 26, Iss 1, Pp 88-88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interferon-gamma release tests kidney transplantation latent tuberculosis infection tuberculin skin test Medicine R
spellingShingle	interferon-gamma release tests kidney transplantation latent tuberculosis infection tuberculin skin test Medicine R Shiva Samavat Sam Alahyari Ali Sangian Malihe Nasiri Mohsen Nafar Ahmad Firoozan Fariba Samadian Nooshin Dalili Fatemeh Poorrezagholi Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates
description	Introduction: Identification of latent tuberculosis (TB) infection is important in kidney transplant candidates. Due to the absence of a gold standard, both tuberculin skin test (TST) and interferon-gamma release assays (IGRA) are used to screen patients. The aim of this study was to evaluate the agreement of these two tests in patients undergoing renal transplantation. Materials and Methods: Two hundred kidney transplant candidates at a referral center in 2014–2017 were included in this study. TST and Quantiferon-Gold (QFT-G) tests were performed for all patients before transplantation. In case of a positive result in any of the tests, patients were administered a 9-month prophylaxis treatment using isoniazid. Cohen's kappa coefficient (k) test was used to determine the agreement between the two tests. Results: The mean age of patients was 40.72 ± 18.33. Nine (4.5%) patients had positive TST and 16 (8%) had positive IGRA. Concordance of the two tests was evaluated as medium (κ = 0.44 and P < 0.001). No association was found between the underlying causes of renal failure and skin test positive or IGRA. The tests showed a poor agreement among diabetics, candidates of re-transplantation, and those who were on dialysis for longer than a year (κ < 0.20). Conclusion: TST or IGRA can be used to screen TB in kidney transplant candidates with a moderate agreement. However, we suggest using both TST and QFT-G in diabetics, re-transplant candidates, and those on dialysis for >1 year.
format	article
author	Shiva Samavat Sam Alahyari Ali Sangian Malihe Nasiri Mohsen Nafar Ahmad Firoozan Fariba Samadian Nooshin Dalili Fatemeh Poorrezagholi
author_facet	Shiva Samavat Sam Alahyari Ali Sangian Malihe Nasiri Mohsen Nafar Ahmad Firoozan Fariba Samadian Nooshin Dalili Fatemeh Poorrezagholi
author_sort	Shiva Samavat
title	Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates
title_short	Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates
title_full	Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates
title_fullStr	Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates
title_full_unstemmed	Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates
title_sort	agreement between the results of tuberculin skin test and interferon-gamma release assays in renal transplant candidates
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/29457a872aee4556bbedf642a4027ae1
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Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates

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