HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

Abstract The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function. Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the...

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Auteurs principaux: Akihisa Okamoto, Chisato Sumi, Hiromasa Tanaka, Munenori Kusunoki, Teppei Iwai, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Keizo Takenaga, Hidemasa Bono, Kiichi Hirota
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/294620230aa444ba9ef9c38cbfc88f43
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https://doaj.org/article/294620230aa444ba9ef9c38cbfc88f43

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