Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny

The identity and origin of adult mammary stem cells has been much debated. Here, the authors use a stochastic genetic labelling approach, together with optical tissue clearing, to visualize clonal progeny and show that unipotent stem/progenitor cells contribute to adult mammary gland development.

Guardado en:

Detalles Bibliográficos
Autores principales:	Felicity M. Davis, Bethan Lloyd-Lewis, Olivia B. Harris, Sarah Kozar, Douglas J. Winton, Leila Muresan, Christine J. Watson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2948887d405f4119b2412369a6efdc95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2948887d405f4119b2412369a6efdc95
record_format	dspace
spelling	oai:doaj.org-article:2948887d405f4119b2412369a6efdc952021-12-02T15:34:52ZSingle-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny10.1038/ncomms130532041-1723https://doaj.org/article/2948887d405f4119b2412369a6efdc952016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13053https://doaj.org/toc/2041-1723The identity and origin of adult mammary stem cells has been much debated. Here, the authors use a stochastic genetic labelling approach, together with optical tissue clearing, to visualize clonal progeny and show that unipotent stem/progenitor cells contribute to adult mammary gland development.Felicity M. DavisBethan Lloyd-LewisOlivia B. HarrisSarah KozarDouglas J. WintonLeila MuresanChristine J. WatsonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felicity M. Davis Bethan Lloyd-Lewis Olivia B. Harris Sarah Kozar Douglas J. Winton Leila Muresan Christine J. Watson Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
description	The identity and origin of adult mammary stem cells has been much debated. Here, the authors use a stochastic genetic labelling approach, together with optical tissue clearing, to visualize clonal progeny and show that unipotent stem/progenitor cells contribute to adult mammary gland development.
format	article
author	Felicity M. Davis Bethan Lloyd-Lewis Olivia B. Harris Sarah Kozar Douglas J. Winton Leila Muresan Christine J. Watson
author_facet	Felicity M. Davis Bethan Lloyd-Lewis Olivia B. Harris Sarah Kozar Douglas J. Winton Leila Muresan Christine J. Watson
author_sort	Felicity M. Davis
title	Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
title_short	Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
title_full	Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
title_fullStr	Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
title_full_unstemmed	Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
title_sort	single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2948887d405f4119b2412369a6efdc95
work_keys_str_mv	AT felicitymdavis singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny AT bethanlloydlewis singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny AT oliviabharris singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny AT sarahkozar singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny AT douglasjwinton singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny AT leilamuresan singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny AT christinejwatson singlecelllineagetracinginthemammaryglandrevealsstochasticclonaldispersionofstemprogenitorcellprogeny
_version_	1718386707575865344

Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny

Ejemplares similares