Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/295c935950d84e4cb61ed4f1f95845a0 |
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| Sumario: | MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency of Microprocessor processing. |
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