Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor

MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency...

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Autores principales:	Shaohua Li, Trung Duc Nguyen, Thuy Linh Nguyen, Tuan Anh Nguyen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/295c935950d84e4cb61ed4f1f95845a0
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spelling	oai:doaj.org-article:295c935950d84e4cb61ed4f1f95845a02021-12-02T14:41:03ZMismatched and wobble base pairs govern primary microRNA processing by human Microprocessor10.1038/s41467-020-15674-22041-1723https://doaj.org/article/295c935950d84e4cb61ed4f1f95845a02020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15674-2https://doaj.org/toc/2041-1723MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency of Microprocessor processing.Shaohua LiTrung Duc NguyenThuy Linh NguyenTuan Anh NguyenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaohua Li Trung Duc Nguyen Thuy Linh Nguyen Tuan Anh Nguyen Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
description	MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency of Microprocessor processing.
format	article
author	Shaohua Li Trung Duc Nguyen Thuy Linh Nguyen Tuan Anh Nguyen
author_facet	Shaohua Li Trung Duc Nguyen Thuy Linh Nguyen Tuan Anh Nguyen
author_sort	Shaohua Li
title	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_short	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_full	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_fullStr	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_full_unstemmed	Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_sort	mismatched and wobble base pairs govern primary microrna processing by human microprocessor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/295c935950d84e4cb61ed4f1f95845a0
work_keys_str_mv	AT shaohuali mismatchedandwobblebasepairsgovernprimarymicrornaprocessingbyhumanmicroprocessor AT trungducnguyen mismatchedandwobblebasepairsgovernprimarymicrornaprocessingbyhumanmicroprocessor AT thuylinhnguyen mismatchedandwobblebasepairsgovernprimarymicrornaprocessingbyhumanmicroprocessor AT tuananhnguyen mismatchedandwobblebasepairsgovernprimarymicrornaprocessingbyhumanmicroprocessor
_version_	1718390042222657536

Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor

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