Body mass index trajectories and the risk for Alzheimer’s disease among older adults

Abstract The effect of body mass index (BMI) changes and variability on the risk for Alzheimer’s disease (AD) remains unclear. We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002–2003), phase 2 (2004–2005), and phase 3 (2006–2007), of the Korean National Health Insurance Servic...

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Autores principales:	Seo Young Kang, Ye-Jee Kim, Wooyoung Jang, Ki Young Son, Hye Soon Park, Young Sik Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2962521921094a76a8ac8e25bcb96697
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spelling	oai:doaj.org-article:2962521921094a76a8ac8e25bcb966972021-12-02T14:06:31ZBody mass index trajectories and the risk for Alzheimer’s disease among older adults10.1038/s41598-021-82593-72045-2322https://doaj.org/article/2962521921094a76a8ac8e25bcb966972021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82593-7https://doaj.org/toc/2045-2322Abstract The effect of body mass index (BMI) changes and variability on the risk for Alzheimer’s disease (AD) remains unclear. We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002–2003), phase 2 (2004–2005), and phase 3 (2006–2007), of the Korean National Health Insurance Service-Health Screening Cohort. We evaluated the effect of 2- and 4-year BMI changes and BMI variability on the risk of AD using Cox regression models. In men, association between 2-year BMI changes, BMI variability, and the risk of AD was not significant. Risk of AD was higher in men whose BMI had decreased 10.1–15.0% over 4 years. In women, aHRs and 95% CIs for AD were 1.14 (1.02–1.29), 1.44 (1.17–1.79), and 1.51 (1.09–2.09) when 2-year BMI loss was 5.1–10.0%, 10.1–15.0%, and > 15.0%. The HRs for AD in women significantly increased when 4-year BMI loss was > 5.0%. The aHR and 95% CI for AD was 1.31 (1.17–1.46) in the 4th quartile of average successive variability (ASV) compared with the 1st quartile of ASV in women. BMI loss over 2- and 4-year period was associated with increased risk for AD, and risk increased in women with higher BMI variability. Appropriate body weight management is recommended to prevent AD.Seo Young KangYe-Jee KimWooyoung JangKi Young SonHye Soon ParkYoung Sik KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seo Young Kang Ye-Jee Kim Wooyoung Jang Ki Young Son Hye Soon Park Young Sik Kim Body mass index trajectories and the risk for Alzheimer’s disease among older adults
description	Abstract The effect of body mass index (BMI) changes and variability on the risk for Alzheimer’s disease (AD) remains unclear. We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002–2003), phase 2 (2004–2005), and phase 3 (2006–2007), of the Korean National Health Insurance Service-Health Screening Cohort. We evaluated the effect of 2- and 4-year BMI changes and BMI variability on the risk of AD using Cox regression models. In men, association between 2-year BMI changes, BMI variability, and the risk of AD was not significant. Risk of AD was higher in men whose BMI had decreased 10.1–15.0% over 4 years. In women, aHRs and 95% CIs for AD were 1.14 (1.02–1.29), 1.44 (1.17–1.79), and 1.51 (1.09–2.09) when 2-year BMI loss was 5.1–10.0%, 10.1–15.0%, and > 15.0%. The HRs for AD in women significantly increased when 4-year BMI loss was > 5.0%. The aHR and 95% CI for AD was 1.31 (1.17–1.46) in the 4th quartile of average successive variability (ASV) compared with the 1st quartile of ASV in women. BMI loss over 2- and 4-year period was associated with increased risk for AD, and risk increased in women with higher BMI variability. Appropriate body weight management is recommended to prevent AD.
format	article
author	Seo Young Kang Ye-Jee Kim Wooyoung Jang Ki Young Son Hye Soon Park Young Sik Kim
author_facet	Seo Young Kang Ye-Jee Kim Wooyoung Jang Ki Young Son Hye Soon Park Young Sik Kim
author_sort	Seo Young Kang
title	Body mass index trajectories and the risk for Alzheimer’s disease among older adults
title_short	Body mass index trajectories and the risk for Alzheimer’s disease among older adults
title_full	Body mass index trajectories and the risk for Alzheimer’s disease among older adults
title_fullStr	Body mass index trajectories and the risk for Alzheimer’s disease among older adults
title_full_unstemmed	Body mass index trajectories and the risk for Alzheimer’s disease among older adults
title_sort	body mass index trajectories and the risk for alzheimer’s disease among older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2962521921094a76a8ac8e25bcb96697
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Body mass index trajectories and the risk for Alzheimer’s disease among older adults

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