Role of cerebral blood flow in extreme breath holding

The role of cerebral blood flow (CBF) on a maximal breath-hold (BH) in ultra-elite divers was examined. Divers (n = 7) performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg). Arterial blood gases and CBF were measured...

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Autores principales:	Bain Anthony R., Ainslie Philip N., Hoiland Ryan L., Willie Chris K., MacLeod David B., Madden Dennis, Maslov Petra Zubin, Drviš Ivan, Dujić Željko
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	apnea cerebral oxygen delivery hypercapnia hypoxia indomethacin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/296363fd70bd484d8cc61d0c4ef821df
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spelling	oai:doaj.org-article:296363fd70bd484d8cc61d0c4ef821df2021-12-05T14:11:04ZRole of cerebral blood flow in extreme breath holding2081-693610.1515/tnsci-2016-0003https://doaj.org/article/296363fd70bd484d8cc61d0c4ef821df2016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0003https://doaj.org/toc/2081-6936The role of cerebral blood flow (CBF) on a maximal breath-hold (BH) in ultra-elite divers was examined. Divers (n = 7) performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg). Arterial blood gases and CBF were measured prior to (baseline), and at BH termination. Compared to control, indomethacin reduced baseline CBF and cerebral delivery of oxygen (CDO2) by about 26% (p < 0.01). Indomethacin reduced maximal BH time from 339 ± 51 to 319 ± 57 seconds (p = 0.04). In both conditions, the CDO2 remained unchanged from baseline to the termination of apnea. At BH termination, arterial oxygen tension was higher following oral administration of indomethacin compared to control (4.05 ± 0.45 vs. 3.44 ± 0.32 kPa). The absolute increase in CBF from baseline to the termination of apnea was lower with indomethacin (p = 0.01). These findings indicate that the impact of CBF on maximal BH time is likely attributable to its influence on cerebral H+ washout, and therefore central chemoreceptive drive to breathe, rather than to CDO2.Bain Anthony R.Ainslie Philip N.Hoiland Ryan L.Willie Chris K.MacLeod David B.Madden DennisMaslov Petra ZubinDrviš IvanDujić ŽeljkoDe Gruyterarticleapneacerebral oxygen deliveryhypercapniahypoxiaindomethacinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 12-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	apnea cerebral oxygen delivery hypercapnia hypoxia indomethacin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	apnea cerebral oxygen delivery hypercapnia hypoxia indomethacin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Bain Anthony R. Ainslie Philip N. Hoiland Ryan L. Willie Chris K. MacLeod David B. Madden Dennis Maslov Petra Zubin Drviš Ivan Dujić Željko Role of cerebral blood flow in extreme breath holding
description	The role of cerebral blood flow (CBF) on a maximal breath-hold (BH) in ultra-elite divers was examined. Divers (n = 7) performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg). Arterial blood gases and CBF were measured prior to (baseline), and at BH termination. Compared to control, indomethacin reduced baseline CBF and cerebral delivery of oxygen (CDO2) by about 26% (p < 0.01). Indomethacin reduced maximal BH time from 339 ± 51 to 319 ± 57 seconds (p = 0.04). In both conditions, the CDO2 remained unchanged from baseline to the termination of apnea. At BH termination, arterial oxygen tension was higher following oral administration of indomethacin compared to control (4.05 ± 0.45 vs. 3.44 ± 0.32 kPa). The absolute increase in CBF from baseline to the termination of apnea was lower with indomethacin (p = 0.01). These findings indicate that the impact of CBF on maximal BH time is likely attributable to its influence on cerebral H+ washout, and therefore central chemoreceptive drive to breathe, rather than to CDO2.
format	article
author	Bain Anthony R. Ainslie Philip N. Hoiland Ryan L. Willie Chris K. MacLeod David B. Madden Dennis Maslov Petra Zubin Drviš Ivan Dujić Željko
author_facet	Bain Anthony R. Ainslie Philip N. Hoiland Ryan L. Willie Chris K. MacLeod David B. Madden Dennis Maslov Petra Zubin Drviš Ivan Dujić Željko
author_sort	Bain Anthony R.
title	Role of cerebral blood flow in extreme breath holding
title_short	Role of cerebral blood flow in extreme breath holding
title_full	Role of cerebral blood flow in extreme breath holding
title_fullStr	Role of cerebral blood flow in extreme breath holding
title_full_unstemmed	Role of cerebral blood flow in extreme breath holding
title_sort	role of cerebral blood flow in extreme breath holding
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/296363fd70bd484d8cc61d0c4ef821df
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Role of cerebral blood flow in extreme breath holding

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