Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease

Abstract Glucose is the central nervous system’s only energy source. Imaging techniques capable to detect pathological alterations of the brain metabolism are useful in different diagnostic processes. Such techniques are also beneficial for assessing the evaluation efficacy of therapies in pre-clini...

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Autores principales:	Daniele Tolomeo, Edoardo Micotti, Sonia Colombo Serra, Michael Chappell, Anniina Snellman, Gianluigi Forloni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2963ada7571f471d909d643ef6001e76
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spelling	oai:doaj.org-article:2963ada7571f471d909d643ef6001e762021-12-02T15:07:59ZChemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease10.1038/s41598-018-27839-72045-2322https://doaj.org/article/2963ada7571f471d909d643ef6001e762018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27839-7https://doaj.org/toc/2045-2322Abstract Glucose is the central nervous system’s only energy source. Imaging techniques capable to detect pathological alterations of the brain metabolism are useful in different diagnostic processes. Such techniques are also beneficial for assessing the evaluation efficacy of therapies in pre-clinical and clinical stages of diseases. Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a possible alternative to positron emission tomography (PET) imaging that has been widely explored in cancer research in humans and animal models. We propose that pathological alterations in brain 2-deoxy-D-glucose (2DG) uptake, typical of neurodegenerative diseases, can be detected with CEST MRI. Transgenic mice overexpressing a mutated form of amyloid precusrsor protein (APP23), a model of Alzheimer’s disease, analyzed with CEST MRI showed a clear reduction of 2DG uptake in different brain regions. This was reminiscent of the cerebral condition observed in Alzheimer’s patients. The results indicate the feasibility of CEST for analyzing the brain metabolic state, with better image resolution than PET in experimental models.Daniele TolomeoEdoardo MicottiSonia Colombo SerraMichael ChappellAnniina SnellmanGianluigi ForloniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniele Tolomeo Edoardo Micotti Sonia Colombo Serra Michael Chappell Anniina Snellman Gianluigi Forloni Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease
description	Abstract Glucose is the central nervous system’s only energy source. Imaging techniques capable to detect pathological alterations of the brain metabolism are useful in different diagnostic processes. Such techniques are also beneficial for assessing the evaluation efficacy of therapies in pre-clinical and clinical stages of diseases. Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a possible alternative to positron emission tomography (PET) imaging that has been widely explored in cancer research in humans and animal models. We propose that pathological alterations in brain 2-deoxy-D-glucose (2DG) uptake, typical of neurodegenerative diseases, can be detected with CEST MRI. Transgenic mice overexpressing a mutated form of amyloid precusrsor protein (APP23), a model of Alzheimer’s disease, analyzed with CEST MRI showed a clear reduction of 2DG uptake in different brain regions. This was reminiscent of the cerebral condition observed in Alzheimer’s patients. The results indicate the feasibility of CEST for analyzing the brain metabolic state, with better image resolution than PET in experimental models.
format	article
author	Daniele Tolomeo Edoardo Micotti Sonia Colombo Serra Michael Chappell Anniina Snellman Gianluigi Forloni
author_facet	Daniele Tolomeo Edoardo Micotti Sonia Colombo Serra Michael Chappell Anniina Snellman Gianluigi Forloni
author_sort	Daniele Tolomeo
title	Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease
title_short	Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease
title_full	Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease
title_fullStr	Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease
title_full_unstemmed	Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease
title_sort	chemical exchange saturation transfer mri shows low cerebral 2-deoxy-d-glucose uptake in a model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2963ada7571f471d909d643ef6001e76
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Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease

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