Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus

Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is <i>Origanum vulgare</i>. Magnolol is...

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Autores principales:	Georgiana Ioana Potra Cicalău, Petru Aurel Babes, Horia Calniceanu, Adelina Popa, Gabriela Ciavoi, Gilda Mihaela Iova, Mariana Ganea, Ioana Scrobotă
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carvacrol magnolol periodontitis diabetes anti-inflammatory antioxidant Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/296660bef2f74cfca7bf81f983503945
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spelling	oai:doaj.org-article:296660bef2f74cfca7bf81f9835039452021-11-25T18:28:13ZAnti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus10.3390/molecules262268991420-3049https://doaj.org/article/296660bef2f74cfca7bf81f9835039452021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6899https://doaj.org/toc/1420-3049Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is <i>Origanum vulgare</i>. Magnolol is a traditional polyphenolic compound isolated from the stem bark of <i>Magnolia officinalis</i>, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.Georgiana Ioana Potra CicalăuPetru Aurel BabesHoria CalniceanuAdelina PopaGabriela CiavoiGilda Mihaela IovaMariana GaneaIoana ScrobotăMDPI AGarticlecarvacrolmagnololperiodontitisdiabetesanti-inflammatoryantioxidantOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6899, p 6899 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carvacrol magnolol periodontitis diabetes anti-inflammatory antioxidant Organic chemistry QD241-441
spellingShingle	carvacrol magnolol periodontitis diabetes anti-inflammatory antioxidant Organic chemistry QD241-441 Georgiana Ioana Potra Cicalău Petru Aurel Babes Horia Calniceanu Adelina Popa Gabriela Ciavoi Gilda Mihaela Iova Mariana Ganea Ioana Scrobotă Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
description	Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is <i>Origanum vulgare</i>. Magnolol is a traditional polyphenolic compound isolated from the stem bark of <i>Magnolia officinalis</i>, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
format	article
author	Georgiana Ioana Potra Cicalău Petru Aurel Babes Horia Calniceanu Adelina Popa Gabriela Ciavoi Gilda Mihaela Iova Mariana Ganea Ioana Scrobotă
author_facet	Georgiana Ioana Potra Cicalău Petru Aurel Babes Horia Calniceanu Adelina Popa Gabriela Ciavoi Gilda Mihaela Iova Mariana Ganea Ioana Scrobotă
author_sort	Georgiana Ioana Potra Cicalău
title	Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
title_short	Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
title_full	Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
title_fullStr	Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
title_full_unstemmed	Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
title_sort	anti-inflammatory and antioxidant properties of carvacrol and magnolol, in periodontal disease and diabetes mellitus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/296660bef2f74cfca7bf81f983503945
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Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus

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