A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute to squamous and glandular epithelia during hom...

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Autores principales: Louciné Mitoyan, Véronique Chevrier, Hector Hernandez-Vargas, Alexane Ollivier, Zeinab Homayed, Julie Pannequin, Flora Poizat, Cécile De Biasi-Cador, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Géraldine Guasch
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/296e414aa37a402286028e30347ff680
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spelling oai:doaj.org-article:296e414aa37a402286028e30347ff6802021-12-02T17:16:10ZA stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration10.1038/s41467-021-23034-x2041-1723https://doaj.org/article/296e414aa37a402286028e30347ff6802021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23034-xhttps://doaj.org/toc/2041-1723Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute to squamous and glandular epithelia during homeostasis and repair.Louciné MitoyanVéronique ChevrierHector Hernandez-VargasAlexane OllivierZeinab HomayedJulie PannequinFlora PoizatCécile De Biasi-CadorEmmanuelle Charafe-JauffretChristophe GinestierGéraldine GuaschNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Louciné Mitoyan
Véronique Chevrier
Hector Hernandez-Vargas
Alexane Ollivier
Zeinab Homayed
Julie Pannequin
Flora Poizat
Cécile De Biasi-Cador
Emmanuelle Charafe-Jauffret
Christophe Ginestier
Géraldine Guasch
A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
description Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute to squamous and glandular epithelia during homeostasis and repair.
format article
author Louciné Mitoyan
Véronique Chevrier
Hector Hernandez-Vargas
Alexane Ollivier
Zeinab Homayed
Julie Pannequin
Flora Poizat
Cécile De Biasi-Cador
Emmanuelle Charafe-Jauffret
Christophe Ginestier
Géraldine Guasch
author_facet Louciné Mitoyan
Véronique Chevrier
Hector Hernandez-Vargas
Alexane Ollivier
Zeinab Homayed
Julie Pannequin
Flora Poizat
Cécile De Biasi-Cador
Emmanuelle Charafe-Jauffret
Christophe Ginestier
Géraldine Guasch
author_sort Louciné Mitoyan
title A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
title_short A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
title_full A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
title_fullStr A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
title_full_unstemmed A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
title_sort stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/296e414aa37a402286028e30347ff680
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