A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study

A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study

Abstract Arteriovenous (AV) fistulas for hemodialysis can lead to cardiac volume loading and increased serum brain natriuretic peptide (BNP) levels. Whether short-term AV loop placement in patients undergoing microsurgery has an impact on cardiac biomarkers and circulating microRNAs (miRNAs), potent...

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Autores principales: Dominic Henn, Masood Abu-Halima, Mustafa Kahraman, Florian Falkner, Katharina S. Fischer, Janos A. Barrera, Kellen Chen, Geoffrey C. Gurtner, Andreas Keller, Ulrich Kneser, Eckart Meese, Volker J. Schmidt
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/296edd7caca7428fbfe74fa6a26aea7c
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spelling oai:doaj.org-article:296edd7caca7428fbfe74fa6a26aea7c2021-12-02T15:11:51ZA multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study10.1038/s41598-020-78905-y2045-2322https://doaj.org/article/296edd7caca7428fbfe74fa6a26aea7c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78905-yhttps://doaj.org/toc/2045-2322Abstract Arteriovenous (AV) fistulas for hemodialysis can lead to cardiac volume loading and increased serum brain natriuretic peptide (BNP) levels. Whether short-term AV loop placement in patients undergoing microsurgery has an impact on cardiac biomarkers and circulating microRNAs (miRNAs), potentially indicating an increased hemodynamic risk, remains elusive. Fifteen patients underwent AV loop placement with delayed free flap anastomosis for microsurgical reconstructions of lower extremity soft-tissue defects. N-terminal pro-BNP (NT-proBNP), copeptin (CT-proAVP), and miRNA expression profiles were determined in the peripheral blood before and after AV loop placement. MiRNA expression in the blood was correlated with miRNA expression from AV loop vascular tissue. Serum NT-proBNP and copeptin levels exceeded the upper reference limit after AV loop placement, with an especially strong NT-proBNP increase in patients with preexistent cardiac diseases. A miRNA signature of 4 up-regulated (miR-3198, miR-3127-5p, miR-1305, miR-1288-3p) and 2 down-regulated miRNAs (miR30a-5p, miR-145-5p) which are related to cardiovascular physiology, showed a significant systemic deregulation in blood and venous tissue after AV loop placement. AV loop placement causes serum elevations of NT-proBNP, copeptin as well as specific circulating miRNAs, indicating a potentially increased hemodynamic risk for patients with cardiovascular comorbidities, if free flap anastomosis is delayed.Dominic HennMasood Abu-HalimaMustafa KahramanFlorian FalknerKatharina S. FischerJanos A. BarreraKellen ChenGeoffrey C. GurtnerAndreas KellerUlrich KneserEckart MeeseVolker J. SchmidtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Dominic Henn
Masood Abu-Halima
Mustafa Kahraman
Florian Falkner
Katharina S. Fischer
Janos A. Barrera
Kellen Chen
Geoffrey C. Gurtner
Andreas Keller
Ulrich Kneser
Eckart Meese
Volker J. Schmidt
A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
description Abstract Arteriovenous (AV) fistulas for hemodialysis can lead to cardiac volume loading and increased serum brain natriuretic peptide (BNP) levels. Whether short-term AV loop placement in patients undergoing microsurgery has an impact on cardiac biomarkers and circulating microRNAs (miRNAs), potentially indicating an increased hemodynamic risk, remains elusive. Fifteen patients underwent AV loop placement with delayed free flap anastomosis for microsurgical reconstructions of lower extremity soft-tissue defects. N-terminal pro-BNP (NT-proBNP), copeptin (CT-proAVP), and miRNA expression profiles were determined in the peripheral blood before and after AV loop placement. MiRNA expression in the blood was correlated with miRNA expression from AV loop vascular tissue. Serum NT-proBNP and copeptin levels exceeded the upper reference limit after AV loop placement, with an especially strong NT-proBNP increase in patients with preexistent cardiac diseases. A miRNA signature of 4 up-regulated (miR-3198, miR-3127-5p, miR-1305, miR-1288-3p) and 2 down-regulated miRNAs (miR30a-5p, miR-145-5p) which are related to cardiovascular physiology, showed a significant systemic deregulation in blood and venous tissue after AV loop placement. AV loop placement causes serum elevations of NT-proBNP, copeptin as well as specific circulating miRNAs, indicating a potentially increased hemodynamic risk for patients with cardiovascular comorbidities, if free flap anastomosis is delayed.
format article
author Dominic Henn
Masood Abu-Halima
Mustafa Kahraman
Florian Falkner
Katharina S. Fischer
Janos A. Barrera
Kellen Chen
Geoffrey C. Gurtner
Andreas Keller
Ulrich Kneser
Eckart Meese
Volker J. Schmidt
author_facet Dominic Henn
Masood Abu-Halima
Mustafa Kahraman
Florian Falkner
Katharina S. Fischer
Janos A. Barrera
Kellen Chen
Geoffrey C. Gurtner
Andreas Keller
Ulrich Kneser
Eckart Meese
Volker J. Schmidt
author_sort Dominic Henn
title A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
title_short A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
title_full A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
title_fullStr A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
title_full_unstemmed A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
title_sort multivariable mirna signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/296edd7caca7428fbfe74fa6a26aea7c
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