Vascular dementia: Pharmacological treatment approaches and perspectives

Andrius Baskys1,3, Anthony C Hou21Department of Psychiatry and Human Behavior; 2Program in Geriatrics, University of California at Irvine, Irvine, California; 3Memory Disorders Program, VA Health Care System Long Beach, Long Beach, California, USAAbstract: Vascular dementia is a common condition for...

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Autores principales:	Andrius Baskys, Anthony C Hou
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/29795eeb009b4d909bd482826fdb7af4
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id	oai:doaj.org-article:29795eeb009b4d909bd482826fdb7af4
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spelling	oai:doaj.org-article:29795eeb009b4d909bd482826fdb7af42021-12-02T02:47:31ZVascular dementia: Pharmacological treatment approaches and perspectives1178-1998https://doaj.org/article/29795eeb009b4d909bd482826fdb7af42007-10-01T00:00:00Zhttps://www.dovepress.com/vascular-dementia-pharmacological-treatment-approaches-and-perspective-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Andrius Baskys1,3, Anthony C Hou21Department of Psychiatry and Human Behavior; 2Program in Geriatrics, University of California at Irvine, Irvine, California; 3Memory Disorders Program, VA Health Care System Long Beach, Long Beach, California, USAAbstract: Vascular dementia is a common condition for which there are no effective approved pharmacological treatments available. Absence of effective treatments creates a difficult situation for those suffering from the disease, their caregivers, and healthcare providers. This review will address our current understanding of the mechanisms of nerve cell damage due to ischemia and summarize available clinical trial data on several commonly used compounds including memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDPcholine, folic acid, as well as such nonpharmacological approaches as validation therapy.Keywords: vascular dementia, excitotoxicity, treatment, NMDA, memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDP-choline, folic acidAndrius BaskysAnthony C HouDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 327-335 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Andrius Baskys Anthony C Hou Vascular dementia: Pharmacological treatment approaches and perspectives
description	Andrius Baskys1,3, Anthony C Hou21Department of Psychiatry and Human Behavior; 2Program in Geriatrics, University of California at Irvine, Irvine, California; 3Memory Disorders Program, VA Health Care System Long Beach, Long Beach, California, USAAbstract: Vascular dementia is a common condition for which there are no effective approved pharmacological treatments available. Absence of effective treatments creates a difficult situation for those suffering from the disease, their caregivers, and healthcare providers. This review will address our current understanding of the mechanisms of nerve cell damage due to ischemia and summarize available clinical trial data on several commonly used compounds including memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDPcholine, folic acid, as well as such nonpharmacological approaches as validation therapy.Keywords: vascular dementia, excitotoxicity, treatment, NMDA, memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDP-choline, folic acid
format	article
author	Andrius Baskys Anthony C Hou
author_facet	Andrius Baskys Anthony C Hou
author_sort	Andrius Baskys
title	Vascular dementia: Pharmacological treatment approaches and perspectives
title_short	Vascular dementia: Pharmacological treatment approaches and perspectives
title_full	Vascular dementia: Pharmacological treatment approaches and perspectives
title_fullStr	Vascular dementia: Pharmacological treatment approaches and perspectives
title_full_unstemmed	Vascular dementia: Pharmacological treatment approaches and perspectives
title_sort	vascular dementia: pharmacological treatment approaches and perspectives
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/29795eeb009b4d909bd482826fdb7af4
work_keys_str_mv	AT andriusbaskys vasculardementiapharmacologicaltreatmentapproachesandperspectives AT anthonychou vasculardementiapharmacologicaltreatmentapproachesandperspectives
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Vascular dementia: Pharmacological treatment approaches and perspectives

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