$Mitochondrial origins of fractional control in regulated cell death$
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Mitochondrial origins of fractional control in regulated cell death

Phenotypic cell-to-cell variability contributes to fractional killing, but the mechanisms are incompletely understood. Here the authors show that mitochondrial density correlates with cell survival in response to TRAIL, and that variable effective concentrations of Bax/Bak contribute to the effect.

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Autores principales:	Luís C. Santos, Robert Vogel, Jerry E. Chipuk, Marc R. Birtwistle, Gustavo Stolovitzky, Pablo Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/297b9e188e2c4c6ba7baf3a2c354a5e1
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spelling	oai:doaj.org-article:297b9e188e2c4c6ba7baf3a2c354a5e12021-12-02T17:01:47ZMitochondrial origins of fractional control in regulated cell death10.1038/s41467-019-09275-x2041-1723https://doaj.org/article/297b9e188e2c4c6ba7baf3a2c354a5e12019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09275-xhttps://doaj.org/toc/2041-1723Phenotypic cell-to-cell variability contributes to fractional killing, but the mechanisms are incompletely understood. Here the authors show that mitochondrial density correlates with cell survival in response to TRAIL, and that variable effective concentrations of Bax/Bak contribute to the effect.Luís C. SantosRobert VogelJerry E. ChipukMarc R. BirtwistleGustavo StolovitzkyPablo MeyerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luís C. Santos Robert Vogel Jerry E. Chipuk Marc R. Birtwistle Gustavo Stolovitzky Pablo Meyer Mitochondrial origins of fractional control in regulated cell death
description	Phenotypic cell-to-cell variability contributes to fractional killing, but the mechanisms are incompletely understood. Here the authors show that mitochondrial density correlates with cell survival in response to TRAIL, and that variable effective concentrations of Bax/Bak contribute to the effect.
format	article
author	Luís C. Santos Robert Vogel Jerry E. Chipuk Marc R. Birtwistle Gustavo Stolovitzky Pablo Meyer
author_facet	Luís C. Santos Robert Vogel Jerry E. Chipuk Marc R. Birtwistle Gustavo Stolovitzky Pablo Meyer
author_sort	Luís C. Santos
title	Mitochondrial origins of fractional control in regulated cell death
title_short	Mitochondrial origins of fractional control in regulated cell death
title_full	Mitochondrial origins of fractional control in regulated cell death
title_fullStr	Mitochondrial origins of fractional control in regulated cell death
title_full_unstemmed	Mitochondrial origins of fractional control in regulated cell death
title_sort	mitochondrial origins of fractional control in regulated cell death
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/297b9e188e2c4c6ba7baf3a2c354a5e1
work_keys_str_mv	AT luiscsantos mitochondrialoriginsoffractionalcontrolinregulatedcelldeath AT robertvogel mitochondrialoriginsoffractionalcontrolinregulatedcelldeath AT jerryechipuk mitochondrialoriginsoffractionalcontrolinregulatedcelldeath AT marcrbirtwistle mitochondrialoriginsoffractionalcontrolinregulatedcelldeath AT gustavostolovitzky mitochondrialoriginsoffractionalcontrolinregulatedcelldeath AT pablomeyer mitochondrialoriginsoffractionalcontrolinregulatedcelldeath
_version_	1718382017434877952

Mitochondrial origins of fractional control in regulated cell death

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