Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients

Abstract Whether red cell distribution width (RDW) can be a potential indicator for diabetic nephropathy (DN) is unknown. A total of 809 type 2 diabetes mellitus (T2D) patients were divided into 4 groups according to the quartiles (Q) of the RDW (%): Q1 ≤ 12.4 (n = 229), 12.4 < Q2 ≤ 12.9 (n = 202...

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Autores principales:	Xiao-fen Xiong, Yuan Yang, Xianghui Chen, Xuejing Zhu, Chun Hu, Yachun Han, Li Zhao, Fuyou Liu, Lin Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/297cf738427946ab8ee90406db93ff18
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spelling	oai:doaj.org-article:297cf738427946ab8ee90406db93ff182021-12-02T12:31:55ZRed cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients10.1038/s41598-017-02904-92045-2322https://doaj.org/article/297cf738427946ab8ee90406db93ff182017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02904-9https://doaj.org/toc/2045-2322Abstract Whether red cell distribution width (RDW) can be a potential indicator for diabetic nephropathy (DN) is unknown. A total of 809 type 2 diabetes mellitus (T2D) patients were divided into 4 groups according to the quartiles (Q) of the RDW (%): Q1 ≤ 12.4 (n = 229), 12.4 < Q2 ≤ 12.9 (n = 202), 12.9 < Q3 < 13.5 (n = 168), Q4 ≥ 13.5 (n = 210). Results showed that the levels in Q4 group was higher in age, disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid and proteinuria but lower in hemoglobin, serum albumin and glycosylated hemoglobin compared to Q1 group. Furthermore, the incidences of DN, diabetic peripheral neuropathy, hypertension and coronary heart disease in the Q3 or Q4 group were higher compared to Q1 group. Medications including calcium channel blockers and antiplatelet therapy also showed higher frequencies in Q3 or Q4 group compared to Q1. Logistic regression indicated that the antiplatelet therapy (OR = 2.065), hypertension (OR = 2.819), creatinine (OR = 4.473) and proteinuria (OR = 2.085) were positively associated with level of Q4 group, but higher hemoglobin (OR = 0.021) and serum Ca2+ (OR = 0.178) were negatively associated with Q4. This data suggest that high level of RDW in T2D patients indicates a higher risk and a poor prognosis for DN.Xiao-fen XiongYuan YangXianghui ChenXuejing ZhuChun HuYachun HanLi ZhaoFuyou LiuLin SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiao-fen Xiong Yuan Yang Xianghui Chen Xuejing Zhu Chun Hu Yachun Han Li Zhao Fuyou Liu Lin Sun Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
description	Abstract Whether red cell distribution width (RDW) can be a potential indicator for diabetic nephropathy (DN) is unknown. A total of 809 type 2 diabetes mellitus (T2D) patients were divided into 4 groups according to the quartiles (Q) of the RDW (%): Q1 ≤ 12.4 (n = 229), 12.4 < Q2 ≤ 12.9 (n = 202), 12.9 < Q3 < 13.5 (n = 168), Q4 ≥ 13.5 (n = 210). Results showed that the levels in Q4 group was higher in age, disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid and proteinuria but lower in hemoglobin, serum albumin and glycosylated hemoglobin compared to Q1 group. Furthermore, the incidences of DN, diabetic peripheral neuropathy, hypertension and coronary heart disease in the Q3 or Q4 group were higher compared to Q1 group. Medications including calcium channel blockers and antiplatelet therapy also showed higher frequencies in Q3 or Q4 group compared to Q1. Logistic regression indicated that the antiplatelet therapy (OR = 2.065), hypertension (OR = 2.819), creatinine (OR = 4.473) and proteinuria (OR = 2.085) were positively associated with level of Q4 group, but higher hemoglobin (OR = 0.021) and serum Ca2+ (OR = 0.178) were negatively associated with Q4. This data suggest that high level of RDW in T2D patients indicates a higher risk and a poor prognosis for DN.
format	article
author	Xiao-fen Xiong Yuan Yang Xianghui Chen Xuejing Zhu Chun Hu Yachun Han Li Zhao Fuyou Liu Lin Sun
author_facet	Xiao-fen Xiong Yuan Yang Xianghui Chen Xuejing Zhu Chun Hu Yachun Han Li Zhao Fuyou Liu Lin Sun
author_sort	Xiao-fen Xiong
title	Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
title_short	Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
title_full	Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
title_fullStr	Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
title_full_unstemmed	Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
title_sort	red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/297cf738427946ab8ee90406db93ff18
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Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients

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