Impaired K+ binding to glial glutamate transporter EAAT1 in migraine

Impaired K+ binding to glial glutamate transporter EAAT1 in migraine

Abstract SLC1A3 encodes the glial glutamate transporter hEAAT1, which removes glutamate from the synaptic cleft via stoichiometrically coupled Na+-K+-H+-glutamate transport. In a young man with migraine with aura including hemiplegia, we identified a novel SLC1A3 mutation that predicts the substitut...

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Autores principales: Peter Kovermann, Margarita Hessel, Daniel Kortzak, Joanna C. Jen, Johannes Koch, Christoph Fahlke, Tobias Freilinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/29823721443a4019960ff51246f63d0e
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