CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS

The aim of present study was to investigate relationships between cytokine-producing potential of immunocompetent blood cells (ICC), and expression of heparanase-1 in stomach adenomas and adenocarcinomas. Cytokine-producing potential of ICC, both spontaneous and induced by polyclonal activators, was...

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Autores principales:	A. V. Vankhalsky, S. A. Arkhipov, S. V. Aidagulova, E. S. Mikhailova, N. A. Varaksin, A. I. Autenshlyus
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	cytokines polyclonal activators index of influence heparanase-1 adenoma adenocarcinoma Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/298b1da60cb4474ebe5b33de8e81b7c2
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spelling	oai:doaj.org-article:298b1da60cb4474ebe5b33de8e81b7c22021-11-18T08:03:45ZCYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS1563-06252313-741X10.15789/1563-0625-2016-3-251-258https://doaj.org/article/298b1da60cb4474ebe5b33de8e81b7c22016-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1037https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of present study was to investigate relationships between cytokine-producing potential of immunocompetent blood cells (ICC), and expression of heparanase-1 in stomach adenomas and adenocarcinomas. Cytokine-producing potential of ICC, both spontaneous and induced by polyclonal activators, was studied in peripheral blood of thirty-two patients with adenomas and thirty-six patients with gastric adenocarcinoma. Appropriate values were expressed as an influence index of polyclonal activators (IIPA) upon the cytokine production. In subjects with gastric adenomas, the IIPA indexes based on IL-1ra, ТNFα, IL- 18, and IFNγ production proved to exceed similar parameters for the patients with adenocarcinomas. Expression of heparanase-1 in epithelium of adenomas varied from 0.27 to 3.00. Similar values for adenomatous stroma varied between 2.27 and 11.48. Meanwhile, the variation limits for heparanase-1 expression in adenocarcinomas (as percentage of specifically stained area) were quite considerable (1.79 to 14.26), due to inclusion of adenocarcinomas at variable differentiation stages. Indexes of heparanase-1 expression were shown to be in direct correlation with numbers of regional lymph node metastases. Multivariate analysis revealed a canonical correlation between the levels of heparanase-1 expression in adenomatous epithelium, and IIPA effects upon production of IL-2, IL-6 and IL-8, as well as with effects of IIPA upon production of IL-18, IL-18BP, and IL-8. A canonical correlation was also noted between the heparanase-1 expression in stroma of adenomas, and IIPA upon IL-1ra, TNFα, IL-18 production. The data suggest an involvement of molecular and cellular mechanisms, mediated by cytokines and heparanase-1, thus providing a common vector promoting tumor progression.A. V. VankhalskyS. A. ArkhipovS. V. AidagulovaE. S. MikhailovaN. A. VaraksinA. I. AutenshlyusSPb RAACIarticlecytokinespolyclonal activatorsindex of influenceheparanase-1adenomaadenocarcinomaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 3, Pp 251-258 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines polyclonal activators index of influence heparanase-1 adenoma adenocarcinoma Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines polyclonal activators index of influence heparanase-1 adenoma adenocarcinoma Immunologic diseases. Allergy RC581-607 A. V. Vankhalsky S. A. Arkhipov S. V. Aidagulova E. S. Mikhailova N. A. Varaksin A. I. Autenshlyus CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS
description	The aim of present study was to investigate relationships between cytokine-producing potential of immunocompetent blood cells (ICC), and expression of heparanase-1 in stomach adenomas and adenocarcinomas. Cytokine-producing potential of ICC, both spontaneous and induced by polyclonal activators, was studied in peripheral blood of thirty-two patients with adenomas and thirty-six patients with gastric adenocarcinoma. Appropriate values were expressed as an influence index of polyclonal activators (IIPA) upon the cytokine production. In subjects with gastric adenomas, the IIPA indexes based on IL-1ra, ТNFα, IL- 18, and IFNγ production proved to exceed similar parameters for the patients with adenocarcinomas. Expression of heparanase-1 in epithelium of adenomas varied from 0.27 to 3.00. Similar values for adenomatous stroma varied between 2.27 and 11.48. Meanwhile, the variation limits for heparanase-1 expression in adenocarcinomas (as percentage of specifically stained area) were quite considerable (1.79 to 14.26), due to inclusion of adenocarcinomas at variable differentiation stages. Indexes of heparanase-1 expression were shown to be in direct correlation with numbers of regional lymph node metastases. Multivariate analysis revealed a canonical correlation between the levels of heparanase-1 expression in adenomatous epithelium, and IIPA effects upon production of IL-2, IL-6 and IL-8, as well as with effects of IIPA upon production of IL-18, IL-18BP, and IL-8. A canonical correlation was also noted between the heparanase-1 expression in stroma of adenomas, and IIPA upon IL-1ra, TNFα, IL-18 production. The data suggest an involvement of molecular and cellular mechanisms, mediated by cytokines and heparanase-1, thus providing a common vector promoting tumor progression.
format	article
author	A. V. Vankhalsky S. A. Arkhipov S. V. Aidagulova E. S. Mikhailova N. A. Varaksin A. I. Autenshlyus
author_facet	A. V. Vankhalsky S. A. Arkhipov S. V. Aidagulova E. S. Mikhailova N. A. Varaksin A. I. Autenshlyus
author_sort	A. V. Vankhalsky
title	CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS
title_short	CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS
title_full	CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS
title_fullStr	CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS
title_full_unstemmed	CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS
title_sort	cytokine-producing function of immunocompetent blood cells and its interrelations with heparanase-1 expression in gastric carcinogenesis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/298b1da60cb4474ebe5b33de8e81b7c2
work_keys_str_mv	AT avvankhalsky cytokineproducingfunctionofimmunocompetentbloodcellsanditsinterrelationswithheparanase1expressioningastriccarcinogenesis AT saarkhipov cytokineproducingfunctionofimmunocompetentbloodcellsanditsinterrelationswithheparanase1expressioningastriccarcinogenesis AT svaidagulova cytokineproducingfunctionofimmunocompetentbloodcellsanditsinterrelationswithheparanase1expressioningastriccarcinogenesis AT esmikhailova cytokineproducingfunctionofimmunocompetentbloodcellsanditsinterrelationswithheparanase1expressioningastriccarcinogenesis AT navaraksin cytokineproducingfunctionofimmunocompetentbloodcellsanditsinterrelationswithheparanase1expressioningastriccarcinogenesis AT aiautenshlyus cytokineproducingfunctionofimmunocompetentbloodcellsanditsinterrelationswithheparanase1expressioningastriccarcinogenesis
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CYTOKINE-PRODUCING FUNCTION OF IMMUNOCOMPETENT BLOOD CELLS AND ITS INTERRELATIONS WITH HEPARANASE-1 EXPRESSION IN GASTRIC CARCINOGENESIS

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