The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle
Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.
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American Society for Microbiology
2021
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oai:doaj.org-article:298b9a6dd03e46b69912ca7d1a027da42021-12-02T18:48:30ZThe DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle2379-507710.1128/mSystems.00397-21https://doaj.org/article/298b9a6dd03e46b69912ca7d1a027da42021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00397-21https://doaj.org/toc/2379-5077 Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.Timothy R. HowardMarni S. CrowTodd M. GrecoKrystal K. LumTuo LiIleana M. CristeaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 3 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Timothy R. Howard Marni S. Crow Todd M. Greco Krystal K. Lum Tuo Li Ileana M. Cristea The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle |
| description |
Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression. |
| format |
article |
| author |
Timothy R. Howard Marni S. Crow Todd M. Greco Krystal K. Lum Tuo Li Ileana M. Cristea |
| author_facet |
Timothy R. Howard Marni S. Crow Todd M. Greco Krystal K. Lum Tuo Li Ileana M. Cristea |
| author_sort |
Timothy R. Howard |
| title |
The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle |
| title_short |
The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle |
| title_full |
The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle |
| title_fullStr |
The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle |
| title_full_unstemmed |
The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle |
| title_sort |
dna sensor ifix drives proteome alterations to mobilize nuclear and cytoplasmic antiviral responses, with its acetylation acting as a localization toggle |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/298b9a6dd03e46b69912ca7d1a027da4 |
| work_keys_str_mv |
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| _version_ |
1718377612258050048 |