In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities

Uncontrollable bleeding is still the main cause of post-traumatic deaths due to the blood loss. Moreover, infectious complication of wound is also still a challenging problem for wound healing. Nevertheless, the currently available hemostasis drugs or materials cannot stanch bleeding well due to sin...

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Autores principales:	Qin Xiaolei, Mukerabigwi Jean Felix, Ma Mingzi, Huang Ruyi, Ma Mengdi, Huang Xueying, Cao Yu, Yu Yang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	chitosan blend hydrogel antibacterial rapid hemostatic wound dressing Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/298e3aaa1c6f43a3a472ed82fa601376
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spelling	oai:doaj.org-article:298e3aaa1c6f43a3a472ed82fa6013762021-12-05T14:10:48ZIn situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities1618-722910.1515/epoly-2021-0062https://doaj.org/article/298e3aaa1c6f43a3a472ed82fa6013762021-08-01T00:00:00Zhttps://doi.org/10.1515/epoly-2021-0062https://doaj.org/toc/1618-7229Uncontrollable bleeding is still the main cause of post-traumatic deaths due to the blood loss. Moreover, infectious complication of wound is also still a challenging problem for wound healing. Nevertheless, the currently available hemostasis drugs or materials cannot stanch bleeding well due to single function, slow in effectiveness, adhere to wounds easily, poor gas permeability, etc. Therefore, it is of a great significance to utilize a biomedical hemostatic material that can stop bleeding quickly, preventing from bacterial infections, and with good biocompatibility properties. Herein chitosan (CS) was modified with gallic acid (GA) and thrombin (TB) to prepare an antibacterial hemostatic composite dressing. The CS-based composite hydrogel dressing was obtained by acylation modification, ultraviolet curing crosslinking method and physical mixing. The in vitro results showed that our prepared CS-based composite hydrogel has obvious burst release and good degradation property. Moreover, the in vivo results showed that it has a strong antibacterial property that is much better than single CS, and it can stop bleeding in 1 min which can promote wound healing. Therefore, the findings of this study is expected to contribute to the future designing of biomedical hemostatic materials with improved properties.Qin XiaoleiMukerabigwi Jean FelixMa MingziHuang RuyiMa MengdiHuang XueyingCao YuYu YangDe Gruyterarticlechitosanblend hydrogelantibacterialrapid hemostaticwound dressingPolymers and polymer manufactureTP1080-1185ENe-Polymers, Vol 21, Iss 1, Pp 606-615 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan blend hydrogel antibacterial rapid hemostatic wound dressing Polymers and polymer manufacture TP1080-1185
spellingShingle	chitosan blend hydrogel antibacterial rapid hemostatic wound dressing Polymers and polymer manufacture TP1080-1185 Qin Xiaolei Mukerabigwi Jean Felix Ma Mingzi Huang Ruyi Ma Mengdi Huang Xueying Cao Yu Yu Yang In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
description	Uncontrollable bleeding is still the main cause of post-traumatic deaths due to the blood loss. Moreover, infectious complication of wound is also still a challenging problem for wound healing. Nevertheless, the currently available hemostasis drugs or materials cannot stanch bleeding well due to single function, slow in effectiveness, adhere to wounds easily, poor gas permeability, etc. Therefore, it is of a great significance to utilize a biomedical hemostatic material that can stop bleeding quickly, preventing from bacterial infections, and with good biocompatibility properties. Herein chitosan (CS) was modified with gallic acid (GA) and thrombin (TB) to prepare an antibacterial hemostatic composite dressing. The CS-based composite hydrogel dressing was obtained by acylation modification, ultraviolet curing crosslinking method and physical mixing. The in vitro results showed that our prepared CS-based composite hydrogel has obvious burst release and good degradation property. Moreover, the in vivo results showed that it has a strong antibacterial property that is much better than single CS, and it can stop bleeding in 1 min which can promote wound healing. Therefore, the findings of this study is expected to contribute to the future designing of biomedical hemostatic materials with improved properties.
format	article
author	Qin Xiaolei Mukerabigwi Jean Felix Ma Mingzi Huang Ruyi Ma Mengdi Huang Xueying Cao Yu Yu Yang
author_facet	Qin Xiaolei Mukerabigwi Jean Felix Ma Mingzi Huang Ruyi Ma Mengdi Huang Xueying Cao Yu Yu Yang
author_sort	Qin Xiaolei
title	In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
title_short	In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
title_full	In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
title_fullStr	In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
title_full_unstemmed	In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
title_sort	in situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/298e3aaa1c6f43a3a472ed82fa601376
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In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities

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