A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT
Abstract Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evalu...
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Nature Portfolio
2021
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oai:doaj.org-article:299298a6867f4b5ebf86aa6ccc64f6a72021-12-02T13:41:43ZA prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT10.1038/s41598-021-88366-62045-2322https://doaj.org/article/299298a6867f4b5ebf86aa6ccc64f6a72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88366-6https://doaj.org/toc/2045-2322Abstract Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving long-term PN. This cross-sectional, case–control study included children older than 9 years undergoing PN for at least 2 years. They were age-, gender- and puberty-matched with healthy controls (1:2). Evaluation included biological assessment of bone metabolism (serum calcium, phosphate, and albumin; urinary calcium and creatinine; 25-OH vitamin D, osteocalcin and PTH), dual X-ray absorptiometry (DXA) and HR-pQCT at the ultradistal tibia and radius. Results are presented as median [range]. Eleven patients (3 girls) with a median age of 16 [9–19] years were included. Bone parameters assessed by HR-pQCT at the ultradistal radius and tibia were similar in patients and controls. Parathyroid hormone (PTH) levels were higher (14 [7–115] vs 16 [12–27]) and osteocalcin levels were lower (44 [15–65] vs 65 [38–142]) in patients than in controls, although within the normal range. Conclusions: there were no differences for compartmental bone densities and microarchitecture in patients undergoing chronic PN. Further longitudinal studies are required to confirm these quite reassuring preliminary results.Typhaine LouazonPierre PoinsotLioara RestierAbdelouahed BelmalihIrène Loras-DuclauxStéphanie MarotteSophie HeissatDidier BarnoudCécile ChambrierCyrille B. ConfavreuxAlain LachauxJustine BacchettaNoel PerettiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Typhaine Louazon Pierre Poinsot Lioara Restier Abdelouahed Belmalih Irène Loras-Duclaux Stéphanie Marotte Sophie Heissat Didier Barnoud Cécile Chambrier Cyrille B. Confavreux Alain Lachaux Justine Bacchetta Noel Peretti A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT |
| description |
Abstract Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving long-term PN. This cross-sectional, case–control study included children older than 9 years undergoing PN for at least 2 years. They were age-, gender- and puberty-matched with healthy controls (1:2). Evaluation included biological assessment of bone metabolism (serum calcium, phosphate, and albumin; urinary calcium and creatinine; 25-OH vitamin D, osteocalcin and PTH), dual X-ray absorptiometry (DXA) and HR-pQCT at the ultradistal tibia and radius. Results are presented as median [range]. Eleven patients (3 girls) with a median age of 16 [9–19] years were included. Bone parameters assessed by HR-pQCT at the ultradistal radius and tibia were similar in patients and controls. Parathyroid hormone (PTH) levels were higher (14 [7–115] vs 16 [12–27]) and osteocalcin levels were lower (44 [15–65] vs 65 [38–142]) in patients than in controls, although within the normal range. Conclusions: there were no differences for compartmental bone densities and microarchitecture in patients undergoing chronic PN. Further longitudinal studies are required to confirm these quite reassuring preliminary results. |
| format |
article |
| author |
Typhaine Louazon Pierre Poinsot Lioara Restier Abdelouahed Belmalih Irène Loras-Duclaux Stéphanie Marotte Sophie Heissat Didier Barnoud Cécile Chambrier Cyrille B. Confavreux Alain Lachaux Justine Bacchetta Noel Peretti |
| author_facet |
Typhaine Louazon Pierre Poinsot Lioara Restier Abdelouahed Belmalih Irène Loras-Duclaux Stéphanie Marotte Sophie Heissat Didier Barnoud Cécile Chambrier Cyrille B. Confavreux Alain Lachaux Justine Bacchetta Noel Peretti |
| author_sort |
Typhaine Louazon |
| title |
A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT |
| title_short |
A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT |
| title_full |
A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT |
| title_fullStr |
A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT |
| title_full_unstemmed |
A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT |
| title_sort |
prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using hr-pqct |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/299298a6867f4b5ebf86aa6ccc64f6a7 |
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