Mesenchymal stem cells in systemic sclerosis therapy

Systemic sclerosis (SSc) is a rare autoimmune disorder with a high mortality rate. There are still many unknowns concerning the pathophysiology of this disease, due to its clinical heterogeneity. Since there is still no curative treatment, researchers focus on finding novel methods to help the patie...

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Autores principales:	Daniel Witold Dudek, Ewa Walczuk, Anna Wajda, Agnieszka Paradowska-Gorycka
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2020
Materias:	systemic sclerosis mesenchymal stem cells cell therapy. Medicine R
Acceso en línea:	https://doaj.org/article/29953b1506164ef2ac2328acf5d0298f
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id	oai:doaj.org-article:29953b1506164ef2ac2328acf5d0298f
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spelling	oai:doaj.org-article:29953b1506164ef2ac2328acf5d0298f2021-12-02T17:18:53ZMesenchymal stem cells in systemic sclerosis therapy0034-62332084-983410.5114/reum.2020.99995https://doaj.org/article/29953b1506164ef2ac2328acf5d0298f2020-10-01T00:00:00Zhttps://www.termedia.pl/Mesenchymal-stem-cells-in-systemic-sclerosis-therapy,18,42090,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Systemic sclerosis (SSc) is a rare autoimmune disorder with a high mortality rate. There are still many unknowns concerning the pathophysiology of this disease, due to its clinical heterogeneity. Since there is still no curative treatment, researchers focus on finding novel methods to help the patients. One of the valid options is cellular therapy, and mesenchymal stem cells (MSCs)-based therapy yields great expectations. These cells possess especially valuable attributes regarding key points of SSc. Nevertheless, the effectiveness and safety of this therapy must undergo a rigorous process of verification. In preclinical trials, animal models proved to be a valuable source of scientific knowledge regarding SSc. Because of that, it has been possible to test autologous or allogeneic MSCs from various sources in many clinical trials. A lot of aspects still have to be determined to assess their potential in the management of SSc, probably in association with other therapies.Daniel Witold DudekEwa WalczukAnna WajdaAgnieszka Paradowska-GoryckaTermedia Publishing Housearticlesystemic sclerosis mesenchymal stem cells cell therapy.MedicineRENRheumatology, Vol 58, Iss 5, Pp 324-330 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic sclerosis mesenchymal stem cells cell therapy. Medicine R
spellingShingle	systemic sclerosis mesenchymal stem cells cell therapy. Medicine R Daniel Witold Dudek Ewa Walczuk Anna Wajda Agnieszka Paradowska-Gorycka Mesenchymal stem cells in systemic sclerosis therapy
description	Systemic sclerosis (SSc) is a rare autoimmune disorder with a high mortality rate. There are still many unknowns concerning the pathophysiology of this disease, due to its clinical heterogeneity. Since there is still no curative treatment, researchers focus on finding novel methods to help the patients. One of the valid options is cellular therapy, and mesenchymal stem cells (MSCs)-based therapy yields great expectations. These cells possess especially valuable attributes regarding key points of SSc. Nevertheless, the effectiveness and safety of this therapy must undergo a rigorous process of verification. In preclinical trials, animal models proved to be a valuable source of scientific knowledge regarding SSc. Because of that, it has been possible to test autologous or allogeneic MSCs from various sources in many clinical trials. A lot of aspects still have to be determined to assess their potential in the management of SSc, probably in association with other therapies.
format	article
author	Daniel Witold Dudek Ewa Walczuk Anna Wajda Agnieszka Paradowska-Gorycka
author_facet	Daniel Witold Dudek Ewa Walczuk Anna Wajda Agnieszka Paradowska-Gorycka
author_sort	Daniel Witold Dudek
title	Mesenchymal stem cells in systemic sclerosis therapy
title_short	Mesenchymal stem cells in systemic sclerosis therapy
title_full	Mesenchymal stem cells in systemic sclerosis therapy
title_fullStr	Mesenchymal stem cells in systemic sclerosis therapy
title_full_unstemmed	Mesenchymal stem cells in systemic sclerosis therapy
title_sort	mesenchymal stem cells in systemic sclerosis therapy
publisher	Termedia Publishing House
publishDate	2020
url	https://doaj.org/article/29953b1506164ef2ac2328acf5d0298f
work_keys_str_mv	AT danielwitolddudek mesenchymalstemcellsinsystemicsclerosistherapy AT ewawalczuk mesenchymalstemcellsinsystemicsclerosistherapy AT annawajda mesenchymalstemcellsinsystemicsclerosistherapy AT agnieszkaparadowskagorycka mesenchymalstemcellsinsystemicsclerosistherapy
_version_	1718381075574554624

Mesenchymal stem cells in systemic sclerosis therapy

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