The Consequences of Biofilm Dispersal on the Host

Abstract Chronic infections are often associated with the presence of a biofilm, a community of microorganisms coexisting within a protective matrix of extracellular polymeric substance. Living within a biofilm can make resident microbes significantly more tolerant to antibiotics in comparison to pl...

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Autores principales:	Derek Fleming, Kendra Rumbaugh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/299593321f3e41ba805015b688e151da
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spelling	oai:doaj.org-article:299593321f3e41ba805015b688e151da2021-12-02T11:40:17ZThe Consequences of Biofilm Dispersal on the Host10.1038/s41598-018-29121-22045-2322https://doaj.org/article/299593321f3e41ba805015b688e151da2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29121-2https://doaj.org/toc/2045-2322Abstract Chronic infections are often associated with the presence of a biofilm, a community of microorganisms coexisting within a protective matrix of extracellular polymeric substance. Living within a biofilm can make resident microbes significantly more tolerant to antibiotics in comparison to planktonic, free-floating cells. Thus, agents that can degrade biofilms are being pursued for clinical applications. While biofilm degrading and dispersing agents may represent attractive adjunctive therapies for biofilm-associated chronic infections, very little is known about how the host responds to the sudden dispersal of biofilm cells. In this study, we found that large-scale, in vivo dispersal of motile biofilm bacteria by glycoside hydrolases caused lethal septicemia in the absence of antibiotic therapy in a mouse wound model. However, when administered prudently, biofilm degrading enzymes had the potential to potentiate the efficacy of antibiotics and help resolve biofilm-associated wound infections.Derek FlemingKendra RumbaughNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Derek Fleming Kendra Rumbaugh The Consequences of Biofilm Dispersal on the Host
description	Abstract Chronic infections are often associated with the presence of a biofilm, a community of microorganisms coexisting within a protective matrix of extracellular polymeric substance. Living within a biofilm can make resident microbes significantly more tolerant to antibiotics in comparison to planktonic, free-floating cells. Thus, agents that can degrade biofilms are being pursued for clinical applications. While biofilm degrading and dispersing agents may represent attractive adjunctive therapies for biofilm-associated chronic infections, very little is known about how the host responds to the sudden dispersal of biofilm cells. In this study, we found that large-scale, in vivo dispersal of motile biofilm bacteria by glycoside hydrolases caused lethal septicemia in the absence of antibiotic therapy in a mouse wound model. However, when administered prudently, biofilm degrading enzymes had the potential to potentiate the efficacy of antibiotics and help resolve biofilm-associated wound infections.
format	article
author	Derek Fleming Kendra Rumbaugh
author_facet	Derek Fleming Kendra Rumbaugh
author_sort	Derek Fleming
title	The Consequences of Biofilm Dispersal on the Host
title_short	The Consequences of Biofilm Dispersal on the Host
title_full	The Consequences of Biofilm Dispersal on the Host
title_fullStr	The Consequences of Biofilm Dispersal on the Host
title_full_unstemmed	The Consequences of Biofilm Dispersal on the Host
title_sort	consequences of biofilm dispersal on the host
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/299593321f3e41ba805015b688e151da
work_keys_str_mv	AT derekfleming theconsequencesofbiofilmdispersalonthehost AT kendrarumbaugh theconsequencesofbiofilmdispersalonthehost AT derekfleming consequencesofbiofilmdispersalonthehost AT kendrarumbaugh consequencesofbiofilmdispersalonthehost
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The Consequences of Biofilm Dispersal on the Host

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