Conformational states of a bacterial α2-macroglobulin resemble those of human complement C3.

α(2) macroglobulins (α(2)Ms) are broad-spectrum protease inhibitors that play essential roles in the innate immune system of eukaryotic species. These large, multi-domain proteins are characterized by a broad-spectrum bait region and an internal thioester, which, upon cleavage, becomes covalently as...

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Autores principales: David Neves, Leandro F Estrozi, Viviana Job, Frank Gabel, Guy Schoehn, Andréa Dessen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/29a3ebb461c4455c9236a40b58ce2f97
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