The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study

The hazard of subsequent arterial embolism and thrombosis (SAET) in patients with lower leg fractures is not yet well demonstrated. The purpose of this study is to determine the correlation between lower leg fracture and SAET in Taiwan. A total of 134,844 patients with lower leg fractures (ICD-9-CM:...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jian-Xun Chen, Shao-Yun Hsu, Mei-Chen Lin, Pin-Keng Shih
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arterial embolism and thrombosis lower leg fractures Medicine R
Acceso en línea:	https://doaj.org/article/29a45567de44412b915f14b09314f0fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:29a45567de44412b915f14b09314f0fe
record_format	dspace
spelling	oai:doaj.org-article:29a45567de44412b915f14b09314f0fe2021-11-25T18:01:41ZThe Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study10.3390/jcm102253122077-0383https://doaj.org/article/29a45567de44412b915f14b09314f0fe2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5312https://doaj.org/toc/2077-0383The hazard of subsequent arterial embolism and thrombosis (SAET) in patients with lower leg fractures is not yet well demonstrated. The purpose of this study is to determine the correlation between lower leg fracture and SAET in Taiwan. A total of 134,844 patients with lower leg fractures (ICD-9-CM: 823) and chronological diagnosis as SAET (ICD-9-CM: 444.22) was matched (1:1) to the non-fracture cohort according to their propensity score (data coming from the National Health Insurance database between January 2000 to December 2012). Patients were matched by age, gender, and comorbidities. The incidence of SAET and correlation between SAET development and lower leg fracture was statistically analyzed, and subgroup analysis categorized by characteristics and comorbidities was conducted as well. The cumulative incidence of SAET was calculated by Kaplan–Meier analysis. Kaplan–Meier analysis plot showed that, by the end of the ten-year follow-up period, the cumulative incidence of SAET was significantly higher for the lower leg fracture cohort than for the non-fracture cohort (log-rank test: <i>p</i> < 0.001). The lower leg fracture, male, elder age (45–64-year-old; ≥65-year-old), hypertension, diabetes mellitus, and gout were significantly associated with lower extremity SAET risk compared with the matched group. There was an inseparable correlation between the lower leg fracture group and the risks of SAET; subgroup analysis by gender (male, female), age (age < 40 years, age 40–64 years, and age > 65 years) and comorbidities (hypertension, diabetes mellitus, and gout) show compatible results as well. Patients with lower leg fracture have a significantly increased risk of SAET since then two years after the fracture. The hazard of SAET was significantly higher in patients with lower leg fracture than in the non-fracture cohort, and the high incidence was found since then two years after fracture. Further studies are warranted.Jian-Xun ChenShao-Yun HsuMei-Chen LinPin-Keng ShihMDPI AGarticlearterial embolism and thrombosislower leg fracturesMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5312, p 5312 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial embolism and thrombosis lower leg fractures Medicine R
spellingShingle	arterial embolism and thrombosis lower leg fractures Medicine R Jian-Xun Chen Shao-Yun Hsu Mei-Chen Lin Pin-Keng Shih The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study
description	The hazard of subsequent arterial embolism and thrombosis (SAET) in patients with lower leg fractures is not yet well demonstrated. The purpose of this study is to determine the correlation between lower leg fracture and SAET in Taiwan. A total of 134,844 patients with lower leg fractures (ICD-9-CM: 823) and chronological diagnosis as SAET (ICD-9-CM: 444.22) was matched (1:1) to the non-fracture cohort according to their propensity score (data coming from the National Health Insurance database between January 2000 to December 2012). Patients were matched by age, gender, and comorbidities. The incidence of SAET and correlation between SAET development and lower leg fracture was statistically analyzed, and subgroup analysis categorized by characteristics and comorbidities was conducted as well. The cumulative incidence of SAET was calculated by Kaplan–Meier analysis. Kaplan–Meier analysis plot showed that, by the end of the ten-year follow-up period, the cumulative incidence of SAET was significantly higher for the lower leg fracture cohort than for the non-fracture cohort (log-rank test: <i>p</i> < 0.001). The lower leg fracture, male, elder age (45–64-year-old; ≥65-year-old), hypertension, diabetes mellitus, and gout were significantly associated with lower extremity SAET risk compared with the matched group. There was an inseparable correlation between the lower leg fracture group and the risks of SAET; subgroup analysis by gender (male, female), age (age < 40 years, age 40–64 years, and age > 65 years) and comorbidities (hypertension, diabetes mellitus, and gout) show compatible results as well. Patients with lower leg fracture have a significantly increased risk of SAET since then two years after the fracture. The hazard of SAET was significantly higher in patients with lower leg fracture than in the non-fracture cohort, and the high incidence was found since then two years after fracture. Further studies are warranted.
format	article
author	Jian-Xun Chen Shao-Yun Hsu Mei-Chen Lin Pin-Keng Shih
author_facet	Jian-Xun Chen Shao-Yun Hsu Mei-Chen Lin Pin-Keng Shih
author_sort	Jian-Xun Chen
title	The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study
title_short	The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study
title_full	The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study
title_fullStr	The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study
title_full_unstemmed	The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study
title_sort	correlation between lower extremity fracture and subsequent arterial embolism and thrombosis—a national population cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/29a45567de44412b915f14b09314f0fe
work_keys_str_mv	AT jianxunchen thecorrelationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT shaoyunhsu thecorrelationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT meichenlin thecorrelationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT pinkengshih thecorrelationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT jianxunchen correlationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT shaoyunhsu correlationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT meichenlin correlationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy AT pinkengshih correlationbetweenlowerextremityfractureandsubsequentarterialembolismandthrombosisanationalpopulationcohortstudy
_version_	1718411730889998336

The Correlation between Lower Extremity Fracture and Subsequent Arterial Embolism and Thrombosis—A National Population Cohort Study

Ejemplares similares