RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cel...

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Autores principales:	Nyam-Osor Chimge, Gillian H. Little, Sanjeev K. Baniwal, Helty Adisetiyo, Ying Xie, Tian Zhang, Andie O’Laughlin, Zhi Y. Liu, Peaches Ulrich, Anthony Martin, Paulette Mhawech-Fauceglia, Matthew J. Ellis, Debu Tripathy, Susan Groshen, Chengyu Liang, Zhe Li, Dustin E. Schones, Baruch Frenkel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29a46757716a45099f150aafec38b489
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spelling	oai:doaj.org-article:29a46757716a45099f150aafec38b4892021-12-02T14:39:29ZRUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer10.1038/ncomms107512041-1723https://doaj.org/article/29a46757716a45099f150aafec38b4892016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10751https://doaj.org/toc/2041-1723The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cell proliferation and mitosis deregulation.Nyam-Osor ChimgeGillian H. LittleSanjeev K. BaniwalHelty AdisetiyoYing XieTian ZhangAndie O’LaughlinZhi Y. LiuPeaches UlrichAnthony MartinPaulette Mhawech-FaucegliaMatthew J. EllisDebu TripathySusan GroshenChengyu LiangZhe LiDustin E. SchonesBaruch FrenkelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nyam-Osor Chimge Gillian H. Little Sanjeev K. Baniwal Helty Adisetiyo Ying Xie Tian Zhang Andie O’Laughlin Zhi Y. Liu Peaches Ulrich Anthony Martin Paulette Mhawech-Fauceglia Matthew J. Ellis Debu Tripathy Susan Groshen Chengyu Liang Zhe Li Dustin E. Schones Baruch Frenkel RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
description	The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cell proliferation and mitosis deregulation.
format	article
author	Nyam-Osor Chimge Gillian H. Little Sanjeev K. Baniwal Helty Adisetiyo Ying Xie Tian Zhang Andie O’Laughlin Zhi Y. Liu Peaches Ulrich Anthony Martin Paulette Mhawech-Fauceglia Matthew J. Ellis Debu Tripathy Susan Groshen Chengyu Liang Zhe Li Dustin E. Schones Baruch Frenkel
author_facet	Nyam-Osor Chimge Gillian H. Little Sanjeev K. Baniwal Helty Adisetiyo Ying Xie Tian Zhang Andie O’Laughlin Zhi Y. Liu Peaches Ulrich Anthony Martin Paulette Mhawech-Fauceglia Matthew J. Ellis Debu Tripathy Susan Groshen Chengyu Liang Zhe Li Dustin E. Schones Baruch Frenkel
author_sort	Nyam-Osor Chimge
title	RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
title_short	RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
title_full	RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
title_fullStr	RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
title_full_unstemmed	RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
title_sort	runx1 prevents oestrogen-mediated axin1 suppression and β-catenin activation in er-positive breast cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/29a46757716a45099f150aafec38b489
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RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

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