RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, resulting in β-catenin signalling-mediated cancer cel...

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Autores principales: Nyam-Osor Chimge, Gillian H. Little, Sanjeev K. Baniwal, Helty Adisetiyo, Ying Xie, Tian Zhang, Andie O’Laughlin, Zhi Y. Liu, Peaches Ulrich, Anthony Martin, Paulette Mhawech-Fauceglia, Matthew J. Ellis, Debu Tripathy, Susan Groshen, Chengyu Liang, Zhe Li, Dustin E. Schones, Baruch Frenkel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/29a46757716a45099f150aafec38b489
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