Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

Abstract Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal...

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Autores principales:	Marijke Grau, Max Jerke, Elie Nader, Alexander Schenk, Celine Renoux, Bianca Collins, Thomas Dietz, Daniel Alexander Bizjak, Philippe Joly, Wilhelm Bloch, Philippe Connes, Aram Prokop
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29a5393257ae454ead8962cdd144b49a
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spelling	oai:doaj.org-article:29a5393257ae454ead8962cdd144b49a2021-12-02T16:08:27ZEffect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients10.1038/s41598-019-48364-12045-2322https://doaj.org/article/29a5393257ae454ead8962cdd144b49a2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48364-1https://doaj.org/toc/2045-2322Abstract Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subjects reached the first ventilatory threshold (VT 1). Blood was sampled at rest and at VT 1. At rest, free haemoglobin level was higher and RBC count, haemoglobin and haematocrit were lower in SCA compared to AA. RBC deformability was lower in SCA. Exercise had no effect on the tested parameters. RBC NO level was higher in SCA compared to AA at rest and significantly decreased after exercise in SCA. This might be related to a reduction in RBC-NO synthase (RBC-NOS) activation which was only observed in SCA after exercise. Free radical levels were higher in SCA at rest but concentration was not affected by exercise. Marker for lipid peroxidation and antioxidative capacity were similar in SCA and AA and not affected by exercise. In conclusion, a single acute submaximal bout of exercise has no deleterious effects on RBC deformability or oxidative stress markers in SCA, and seems to modulate RBC-NOS signalling pathway.Marijke GrauMax JerkeElie NaderAlexander SchenkCeline RenouxBianca CollinsThomas DietzDaniel Alexander BizjakPhilippe JolyWilhelm BlochPhilippe ConnesAram ProkopNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marijke Grau Max Jerke Elie Nader Alexander Schenk Celine Renoux Bianca Collins Thomas Dietz Daniel Alexander Bizjak Philippe Joly Wilhelm Bloch Philippe Connes Aram Prokop Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
description	Abstract Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subjects reached the first ventilatory threshold (VT 1). Blood was sampled at rest and at VT 1. At rest, free haemoglobin level was higher and RBC count, haemoglobin and haematocrit were lower in SCA compared to AA. RBC deformability was lower in SCA. Exercise had no effect on the tested parameters. RBC NO level was higher in SCA compared to AA at rest and significantly decreased after exercise in SCA. This might be related to a reduction in RBC-NO synthase (RBC-NOS) activation which was only observed in SCA after exercise. Free radical levels were higher in SCA at rest but concentration was not affected by exercise. Marker for lipid peroxidation and antioxidative capacity were similar in SCA and AA and not affected by exercise. In conclusion, a single acute submaximal bout of exercise has no deleterious effects on RBC deformability or oxidative stress markers in SCA, and seems to modulate RBC-NOS signalling pathway.
format	article
author	Marijke Grau Max Jerke Elie Nader Alexander Schenk Celine Renoux Bianca Collins Thomas Dietz Daniel Alexander Bizjak Philippe Joly Wilhelm Bloch Philippe Connes Aram Prokop
author_facet	Marijke Grau Max Jerke Elie Nader Alexander Schenk Celine Renoux Bianca Collins Thomas Dietz Daniel Alexander Bizjak Philippe Joly Wilhelm Bloch Philippe Connes Aram Prokop
author_sort	Marijke Grau
title	Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
title_short	Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
title_full	Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
title_fullStr	Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
title_full_unstemmed	Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
title_sort	effect of acute exercise on rbc deformability and rbc nitric oxide synthase signalling pathway in young sickle cell anaemia patients
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/29a5393257ae454ead8962cdd144b49a
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Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

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