Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans

Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans

Attachment of the oligosaccharide Man9GlcNAc2 is required for glycoprotein folding and secretion but synthesizing this compound for structural and functional studies has remained challenging. Here, the authors achieve efficient Man9GlcNAc2 synthesis by reconstituting its biosynthetic pathway in vitr...

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Autores principales: Sheng-Tao Li, Tian-Tian Lu, Xin-Xin Xu, Yi Ding, Zijie Li, Toshihiko Kitajima, Neta Dean, Ning Wang, Xiao-Dong Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/29a5c7cd42d945a9960434571e434f91
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