Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS). Here the authors characterize FUS-binding to U1 snRNP and show that ALS-associated FUS aberrantly contacts U1 snRNA which interferes with its biogenesis pathway.
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Nature Portfolio
2020
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oai:doaj.org-article:29a7f401a44547198252c6ea20fa553a2021-12-02T13:24:34ZAberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis10.1038/s41467-020-20191-32041-1723https://doaj.org/article/29a7f401a44547198252c6ea20fa553a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20191-3https://doaj.org/toc/2041-1723Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS). Here the authors characterize FUS-binding to U1 snRNP and show that ALS-associated FUS aberrantly contacts U1 snRNA which interferes with its biogenesis pathway.Daniel JutziSébastien CampagneRalf SchmidtStefan ReberJonas MechtersheimerFoivos GypasChristoph SchweingruberMartino ColomboChristine von SchroetterFionna E. LoughlinAnny DevoyEva HedlundMihaela ZavolanFrédéric H.-T. AllainMarc-David RueppNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Daniel Jutzi Sébastien Campagne Ralf Schmidt Stefan Reber Jonas Mechtersheimer Foivos Gypas Christoph Schweingruber Martino Colombo Christine von Schroetter Fionna E. Loughlin Anny Devoy Eva Hedlund Mihaela Zavolan Frédéric H.-T. Allain Marc-David Ruepp Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis |
| description |
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS). Here the authors characterize FUS-binding to U1 snRNP and show that ALS-associated FUS aberrantly contacts U1 snRNA which interferes with its biogenesis pathway. |
| format |
article |
| author |
Daniel Jutzi Sébastien Campagne Ralf Schmidt Stefan Reber Jonas Mechtersheimer Foivos Gypas Christoph Schweingruber Martino Colombo Christine von Schroetter Fionna E. Loughlin Anny Devoy Eva Hedlund Mihaela Zavolan Frédéric H.-T. Allain Marc-David Ruepp |
| author_facet |
Daniel Jutzi Sébastien Campagne Ralf Schmidt Stefan Reber Jonas Mechtersheimer Foivos Gypas Christoph Schweingruber Martino Colombo Christine von Schroetter Fionna E. Loughlin Anny Devoy Eva Hedlund Mihaela Zavolan Frédéric H.-T. Allain Marc-David Ruepp |
| author_sort |
Daniel Jutzi |
| title |
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis |
| title_short |
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis |
| title_full |
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis |
| title_fullStr |
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis |
| title_full_unstemmed |
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis |
| title_sort |
aberrant interaction of fus with the u1 snrna provides a molecular mechanism of fus induced amyotrophic lateral sclerosis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/29a7f401a44547198252c6ea20fa553a |
| work_keys_str_mv |
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| _version_ |
1718393083722203136 |