MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an...

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Autores principales:	Yahui Yan, Claudia Rato, Lukas Rohland, Steffen Preissler, David Ron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29a9184db10c451b966d07b035dde1b3
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spelling	oai:doaj.org-article:29a9184db10c451b966d07b035dde1b32021-12-02T14:40:17ZMANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP10.1038/s41467-019-08450-42041-1723https://doaj.org/article/29a9184db10c451b966d07b035dde1b32019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08450-4https://doaj.org/toc/2041-1723The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an anti-nucleotide exchange factor for BiP.Yahui YanClaudia RatoLukas RohlandSteffen PreisslerDavid RonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yahui Yan Claudia Rato Lukas Rohland Steffen Preissler David Ron MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
description	The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an anti-nucleotide exchange factor for BiP.
format	article
author	Yahui Yan Claudia Rato Lukas Rohland Steffen Preissler David Ron
author_facet	Yahui Yan Claudia Rato Lukas Rohland Steffen Preissler David Ron
author_sort	Yahui Yan
title	MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
title_short	MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
title_full	MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
title_fullStr	MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
title_full_unstemmed	MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
title_sort	manf antagonizes nucleotide exchange by the endoplasmic reticulum chaperone bip
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/29a9184db10c451b966d07b035dde1b3
work_keys_str_mv	AT yahuiyan manfantagonizesnucleotideexchangebytheendoplasmicreticulumchaperonebip AT claudiarato manfantagonizesnucleotideexchangebytheendoplasmicreticulumchaperonebip AT lukasrohland manfantagonizesnucleotideexchangebytheendoplasmicreticulumchaperonebip AT steffenpreissler manfantagonizesnucleotideexchangebytheendoplasmicreticulumchaperonebip AT davidron manfantagonizesnucleotideexchangebytheendoplasmicreticulumchaperonebip
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MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

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