MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an...

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Autores principales: Yahui Yan, Claudia Rato, Lukas Rohland, Steffen Preissler, David Ron
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/29a9184db10c451b966d07b035dde1b3
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