Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease

Objective: This study aimed to examine the relationships among N, N-dimethylformamide (DMF) exposure, cytochrome P4502E1 (CYP2E1) single nucleotide polymorphisms (SNPs) (rs2031920, rs3813867, rs6413432), transmembrane 6 superfamily member 2 (TM6SF2) SNP rs58542926 and non-alcoholic fatty liver disea...

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Autores principales:	Ziqi Zhou, Lingli Sang, Jin Wang, Lin Song, Lejia Zhu, Yangmei Wang, Jing Xiao, Yulong Lian
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Non-alcoholic fatty liver disease CYP2E1 TM6SF2 N, N-dimethylformamide Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/29ad12f7b67945449855e3971d3fefcc
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spelling	oai:doaj.org-article:29ad12f7b67945449855e3971d3fefcc2021-11-18T04:43:17ZRelationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease0147-651310.1016/j.ecoenv.2021.112986https://doaj.org/article/29ad12f7b67945449855e3971d3fefcc2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010988https://doaj.org/toc/0147-6513Objective: This study aimed to examine the relationships among N, N-dimethylformamide (DMF) exposure, cytochrome P4502E1 (CYP2E1) single nucleotide polymorphisms (SNPs) (rs2031920, rs3813867, rs6413432), transmembrane 6 superfamily member 2 (TM6SF2) SNP rs58542926 and non-alcoholic fatty liver disease (NAFLD). Methods: Baseline data were collected from participants who were then followed for 5 years in a prospective cohort study. The cohort initially consisted of 802 workers and ultimately included 660 people, all of whom underwent annual occupational health examinations from 2010 to 2015. Results: The above-threshold group (≥7.3 mg/m³ adjusted relative risk (RR)= 3.620, 95%CI 2.072–6.325) was significantly more likely to develop NAFLD than the below-threshold group (<7.3 mg/m³). The TM6SF2 SNP rs58542926 CT (adjusted RR=3.921, 95% CI 2.329–6.600, P = 0.000) and CT+TT (adjusted RR=4.385, 95% CI 2.639–7.287, P = 0.000) genotypes were risk factors for NAFLD, as compared with the TM6SF2 rs58542926 CC genotype. Each dose group (below-threshold group and above-threshold group) interacting with the genotype of TM6SF2 SNP rs58542926 had an adjusted RR from 7.764 (95% CI 3.272–18.420, P = 0.000) to 24.022 (95% CI 8.971–64.328, P = 0.000). The T allele of rs58542926 in the TM6SF2 gene may be a risk factor for susceptibility to DMF-induced NAFLD. Conclusion: Polymorphisms of TM6SF2 SNP rs58542926 may play an important role in susceptibility to NAFLD after exposure to DMF.Ziqi ZhouLingli SangJin WangLin SongLejia ZhuYangmei WangJing XiaoYulong LianElsevierarticleNon-alcoholic fatty liver diseaseCYP2E1TM6SF2N, N-dimethylformamideEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112986- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-alcoholic fatty liver disease CYP2E1 TM6SF2 N, N-dimethylformamide Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Non-alcoholic fatty liver disease CYP2E1 TM6SF2 N, N-dimethylformamide Environmental pollution TD172-193.5 Environmental sciences GE1-350 Ziqi Zhou Lingli Sang Jin Wang Lin Song Lejia Zhu Yangmei Wang Jing Xiao Yulong Lian Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
description	Objective: This study aimed to examine the relationships among N, N-dimethylformamide (DMF) exposure, cytochrome P4502E1 (CYP2E1) single nucleotide polymorphisms (SNPs) (rs2031920, rs3813867, rs6413432), transmembrane 6 superfamily member 2 (TM6SF2) SNP rs58542926 and non-alcoholic fatty liver disease (NAFLD). Methods: Baseline data were collected from participants who were then followed for 5 years in a prospective cohort study. The cohort initially consisted of 802 workers and ultimately included 660 people, all of whom underwent annual occupational health examinations from 2010 to 2015. Results: The above-threshold group (≥7.3 mg/m³ adjusted relative risk (RR)= 3.620, 95%CI 2.072–6.325) was significantly more likely to develop NAFLD than the below-threshold group (<7.3 mg/m³). The TM6SF2 SNP rs58542926 CT (adjusted RR=3.921, 95% CI 2.329–6.600, P = 0.000) and CT+TT (adjusted RR=4.385, 95% CI 2.639–7.287, P = 0.000) genotypes were risk factors for NAFLD, as compared with the TM6SF2 rs58542926 CC genotype. Each dose group (below-threshold group and above-threshold group) interacting with the genotype of TM6SF2 SNP rs58542926 had an adjusted RR from 7.764 (95% CI 3.272–18.420, P = 0.000) to 24.022 (95% CI 8.971–64.328, P = 0.000). The T allele of rs58542926 in the TM6SF2 gene may be a risk factor for susceptibility to DMF-induced NAFLD. Conclusion: Polymorphisms of TM6SF2 SNP rs58542926 may play an important role in susceptibility to NAFLD after exposure to DMF.
format	article
author	Ziqi Zhou Lingli Sang Jin Wang Lin Song Lejia Zhu Yangmei Wang Jing Xiao Yulong Lian
author_facet	Ziqi Zhou Lingli Sang Jin Wang Lin Song Lejia Zhu Yangmei Wang Jing Xiao Yulong Lian
author_sort	Ziqi Zhou
title	Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
title_short	Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
title_full	Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
title_fullStr	Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
title_full_unstemmed	Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
title_sort	relationships among n,n-dimethylformamide exposure, cyp2e1 and tm6sf2 genes, and non-alcoholic fatty liver disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/29ad12f7b67945449855e3971d3fefcc
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Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease

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