Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)

This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were...

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Autores principales:	Rajmohamed Mohammed Asik, Chidhambaram Manikkaraja, Karuppusamy Tamil Surya, Natarajan Suganthy, Archunan Priya Aarthy, Domokos Mathe, Muthusamy Sivakumar, Govindaraju Archunan, Parasuraman Padmanabhan, Balazs Gulyas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anticancer activity L-histidine silver nanoparticles cervical cancer cells apoptosis Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/29af6f5d0eb1465396c2f6f3d227646a
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spelling	oai:doaj.org-article:29af6f5d0eb1465396c2f6f3d227646a2021-11-25T18:32:52ZAnticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)10.3390/nano111131542079-4991https://doaj.org/article/29af6f5d0eb1465396c2f6f3d227646a2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/3154https://doaj.org/toc/2079-4991This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of −20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC<sub>50</sub> value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.Rajmohamed Mohammed AsikChidhambaram ManikkarajaKaruppusamy Tamil SuryaNatarajan SuganthyArchunan Priya AarthyDomokos MatheMuthusamy SivakumarGovindaraju ArchunanParasuraman PadmanabhanBalazs GulyasMDPI AGarticleanticancer activityL-histidinesilver nanoparticlescervical cancer cellsapoptosisChemistryQD1-999ENNanomaterials, Vol 11, Iss 3154, p 3154 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer activity L-histidine silver nanoparticles cervical cancer cells apoptosis Chemistry QD1-999
spellingShingle	anticancer activity L-histidine silver nanoparticles cervical cancer cells apoptosis Chemistry QD1-999 Rajmohamed Mohammed Asik Chidhambaram Manikkaraja Karuppusamy Tamil Surya Natarajan Suganthy Archunan Priya Aarthy Domokos Mathe Muthusamy Sivakumar Govindaraju Archunan Parasuraman Padmanabhan Balazs Gulyas Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
description	This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of −20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC<sub>50</sub> value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.
format	article
author	Rajmohamed Mohammed Asik Chidhambaram Manikkaraja Karuppusamy Tamil Surya Natarajan Suganthy Archunan Priya Aarthy Domokos Mathe Muthusamy Sivakumar Govindaraju Archunan Parasuraman Padmanabhan Balazs Gulyas
author_facet	Rajmohamed Mohammed Asik Chidhambaram Manikkaraja Karuppusamy Tamil Surya Natarajan Suganthy Archunan Priya Aarthy Domokos Mathe Muthusamy Sivakumar Govindaraju Archunan Parasuraman Padmanabhan Balazs Gulyas
author_sort	Rajmohamed Mohammed Asik
title	Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
title_short	Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
title_full	Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
title_fullStr	Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
title_full_unstemmed	Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
title_sort	anticancer potential of l-histidine-capped silver nanoparticles against human cervical cancer cells (siha)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/29af6f5d0eb1465396c2f6f3d227646a
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Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)

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