In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli

The large and small subunits of the ribosome are synthesized independently within the nucleolus — a membrane-less compartment within the nucleus — before being exported into the cytoplasm. Here, the authors use in situ cryo-ET to observe ribosome maturation and reveal the native organization of the...

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Auteurs principaux:	Philipp S. Erdmann, Zhen Hou, Sven Klumpe, Sagar Khavnekar, Florian Beck, Florian Wilfling, Jürgen M. Plitzko, Wolfgang Baumeister
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/29af8d2ce12c4b48a297291bce32bf53
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spelling	oai:doaj.org-article:29af8d2ce12c4b48a297291bce32bf532021-12-02T17:19:40ZIn situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli10.1038/s41467-021-25413-w2041-1723https://doaj.org/article/29af8d2ce12c4b48a297291bce32bf532021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25413-whttps://doaj.org/toc/2041-1723The large and small subunits of the ribosome are synthesized independently within the nucleolus — a membrane-less compartment within the nucleus — before being exported into the cytoplasm. Here, the authors use in situ cryo-ET to observe ribosome maturation and reveal the native organization of the nucleolus.Philipp S. ErdmannZhen HouSven KlumpeSagar KhavnekarFlorian BeckFlorian WilflingJürgen M. PlitzkoWolfgang BaumeisterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philipp S. Erdmann Zhen Hou Sven Klumpe Sagar Khavnekar Florian Beck Florian Wilfling Jürgen M. Plitzko Wolfgang Baumeister In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
description	The large and small subunits of the ribosome are synthesized independently within the nucleolus — a membrane-less compartment within the nucleus — before being exported into the cytoplasm. Here, the authors use in situ cryo-ET to observe ribosome maturation and reveal the native organization of the nucleolus.
format	article
author	Philipp S. Erdmann Zhen Hou Sven Klumpe Sagar Khavnekar Florian Beck Florian Wilfling Jürgen M. Plitzko Wolfgang Baumeister
author_facet	Philipp S. Erdmann Zhen Hou Sven Klumpe Sagar Khavnekar Florian Beck Florian Wilfling Jürgen M. Plitzko Wolfgang Baumeister
author_sort	Philipp S. Erdmann
title	In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
title_short	In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
title_full	In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
title_fullStr	In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
title_full_unstemmed	In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
title_sort	in situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29af8d2ce12c4b48a297291bce32bf53
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In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli

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