Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells

Infections induce activation of naïve T cells for protective immunity, but insights for this host-pathogen crosstalk are still missing. Here the authors show that infection-induced type I interferon (IFN-I) signaling promote the differentiation, expansion and functional maturation of naïve CD8 T cel...

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Autores principales:	Mladen Jergović, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Žugich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29b1820501044762b875464f250b653b
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spelling	oai:doaj.org-article:29b1820501044762b875464f250b653b2021-12-02T17:42:11ZInfection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells10.1038/s41467-021-25645-w2041-1723https://doaj.org/article/29b1820501044762b875464f250b653b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25645-whttps://doaj.org/toc/2041-1723Infections induce activation of naïve T cells for protective immunity, but insights for this host-pathogen crosstalk are still missing. Here the authors show that infection-induced type I interferon (IFN-I) signaling promote the differentiation, expansion and functional maturation of naïve CD8 T cells, particularly for low affinity clones, to enhance anti-microbial immunity.Mladen JergovićChristopher P. CoplenJennifer L. UhrlaubDavid G. BesselsenShu ChengMegan J. SmitheyJanko Nikolich-ŽugichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mladen Jergović Christopher P. Coplen Jennifer L. Uhrlaub David G. Besselsen Shu Cheng Megan J. Smithey Janko Nikolich-Žugich Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
description	Infections induce activation of naïve T cells for protective immunity, but insights for this host-pathogen crosstalk are still missing. Here the authors show that infection-induced type I interferon (IFN-I) signaling promote the differentiation, expansion and functional maturation of naïve CD8 T cells, particularly for low affinity clones, to enhance anti-microbial immunity.
format	article
author	Mladen Jergović Christopher P. Coplen Jennifer L. Uhrlaub David G. Besselsen Shu Cheng Megan J. Smithey Janko Nikolich-Žugich
author_facet	Mladen Jergović Christopher P. Coplen Jennifer L. Uhrlaub David G. Besselsen Shu Cheng Megan J. Smithey Janko Nikolich-Žugich
author_sort	Mladen Jergović
title	Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
title_short	Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
title_full	Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
title_fullStr	Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
title_full_unstemmed	Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells
title_sort	infection-induced type i interferons critically modulate the homeostasis and function of cd8+ naïve t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29b1820501044762b875464f250b653b
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Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells

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