Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis

Abstract The pathophysiology and risk factors of nonalcoholic fatty liver disease (NAFLD) among lean patients is poorly understood and therefore investigated. We performed a meta‐analysis of observational studies. Of 1175 articles found through searching from Medline/PubMed, Banglajol, and Google Sc...

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Autores principales:	Shahinul Alam, Mohammad Eslam, Nazmul SKMHasan, Kamrul Anam, Muhammad Abdul Baker Chowdhury, Md Abdullah Saeed Khan, Mohammad J Hasan, Rosmawati Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	lean meta‐analysis nonalcoholic fatty liver disease nonalcoholic steatohepatitis nonlean nonobese Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/29b2ed3fce0c4f39a4bd74ade5c87eea
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spelling	oai:doaj.org-article:29b2ed3fce0c4f39a4bd74ade5c87eea2021-11-18T11:25:44ZRisk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis2397-907010.1002/jgh3.12658https://doaj.org/article/29b2ed3fce0c4f39a4bd74ade5c87eea2021-11-01T00:00:00Zhttps://doi.org/10.1002/jgh3.12658https://doaj.org/toc/2397-9070Abstract The pathophysiology and risk factors of nonalcoholic fatty liver disease (NAFLD) among lean patients is poorly understood and therefore investigated. We performed a meta‐analysis of observational studies. Of 1175 articles found through searching from Medline/PubMed, Banglajol, and Google Scholar by two independent investigators, 22 were selected. Data from lean (n = 6768) and obese (n = 9253) patients with NAFLD were analyzed; lean (n = 43 398) and obese (n = 9619) subjects without NAFLD served as controls. Age, body mass index, waist circumference, systolic blood pressure, and diastolic blood pressure (DBP) had significantly higher estimates in lean NAFLD patients than in lean non‐NAFLD controls. Fasting blood sugar [MD(mean difference) 5.17 mg/dl, 95% CI(confidence interval) 4.14–6.16], HbA1c [MD 0.29%, 95% CI 0.11–0.48], and insulin resistance [HOMA‐IR] [MD 0.49 U, 95% CI 0.29–0.68]) were higher in lean NAFLD patients than in lean non‐NAFLD controls. All components of the lipid profile were raised significantly in the former group except high‐density lipoprotein. An increased uric acid (UA) level was found to be associated with the presence of NAFLD among lean. Cardio‐metabolic profiles of nonlean NAFLD patients significantly differs from the counter group. However, the magnitude of the difference of lipid and glycemic profile barely reached statistical significance when subjects were grouped according to lean and nonlean NAFLD. But DBP (slope: 0.19, P < 0.037), HOMA‐IR (slope: 0.58, P < 0.001), and UA (slope: 0.36, P = 0.022) were significantly higher if NAFLD was present compared to that of non‐NAFLD group. Lean and nonlean NAFLD patients are metabolically similar and share common risk factors.Shahinul AlamMohammad EslamNazmul SKMHasanKamrul AnamMuhammad Abdul Baker ChowdhuryMd Abdullah Saeed KhanMohammad J HasanRosmawati MohamedWileyarticleleanmeta‐analysisnonalcoholic fatty liver diseasenonalcoholic steatohepatitisnonleannonobeseDiseases of the digestive system. GastroenterologyRC799-869ENJGH Open, Vol 5, Iss 11, Pp 1236-1249 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lean meta‐analysis nonalcoholic fatty liver disease nonalcoholic steatohepatitis nonlean nonobese Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	lean meta‐analysis nonalcoholic fatty liver disease nonalcoholic steatohepatitis nonlean nonobese Diseases of the digestive system. Gastroenterology RC799-869 Shahinul Alam Mohammad Eslam Nazmul SKMHasan Kamrul Anam Muhammad Abdul Baker Chowdhury Md Abdullah Saeed Khan Mohammad J Hasan Rosmawati Mohamed Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis
description	Abstract The pathophysiology and risk factors of nonalcoholic fatty liver disease (NAFLD) among lean patients is poorly understood and therefore investigated. We performed a meta‐analysis of observational studies. Of 1175 articles found through searching from Medline/PubMed, Banglajol, and Google Scholar by two independent investigators, 22 were selected. Data from lean (n = 6768) and obese (n = 9253) patients with NAFLD were analyzed; lean (n = 43 398) and obese (n = 9619) subjects without NAFLD served as controls. Age, body mass index, waist circumference, systolic blood pressure, and diastolic blood pressure (DBP) had significantly higher estimates in lean NAFLD patients than in lean non‐NAFLD controls. Fasting blood sugar [MD(mean difference) 5.17 mg/dl, 95% CI(confidence interval) 4.14–6.16], HbA1c [MD 0.29%, 95% CI 0.11–0.48], and insulin resistance [HOMA‐IR] [MD 0.49 U, 95% CI 0.29–0.68]) were higher in lean NAFLD patients than in lean non‐NAFLD controls. All components of the lipid profile were raised significantly in the former group except high‐density lipoprotein. An increased uric acid (UA) level was found to be associated with the presence of NAFLD among lean. Cardio‐metabolic profiles of nonlean NAFLD patients significantly differs from the counter group. However, the magnitude of the difference of lipid and glycemic profile barely reached statistical significance when subjects were grouped according to lean and nonlean NAFLD. But DBP (slope: 0.19, P < 0.037), HOMA‐IR (slope: 0.58, P < 0.001), and UA (slope: 0.36, P = 0.022) were significantly higher if NAFLD was present compared to that of non‐NAFLD group. Lean and nonlean NAFLD patients are metabolically similar and share common risk factors.
format	article
author	Shahinul Alam Mohammad Eslam Nazmul SKMHasan Kamrul Anam Muhammad Abdul Baker Chowdhury Md Abdullah Saeed Khan Mohammad J Hasan Rosmawati Mohamed
author_facet	Shahinul Alam Mohammad Eslam Nazmul SKMHasan Kamrul Anam Muhammad Abdul Baker Chowdhury Md Abdullah Saeed Khan Mohammad J Hasan Rosmawati Mohamed
author_sort	Shahinul Alam
title	Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis
title_short	Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis
title_full	Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis
title_fullStr	Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis
title_full_unstemmed	Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis
title_sort	risk factors of nonalcoholic fatty liver disease in lean body mass population: a systematic review and meta‐analysis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/29b2ed3fce0c4f39a4bd74ade5c87eea
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Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta‐analysis

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