Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy

Rui-Meng Yang,1,* Chao-Ping Fu,2,* Jin-Zhi Fang,1 Xiang-Dong Xu,1 Xin-Hua Wei,1 Wen-Jie Tang,1 Xin-Qing Jiang,1 Li-Ming Zhang2 1Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, 2School of Materials Science and Engineering, School of Chemistry, Sun...

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Autores principales:	Yang R, Fu C, Fang J, Xu X, Wei X, Tang W, Jiang X, Zhang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	iron oxide nanoparticles surface functionalization bioactive glycosaminoglycan magnetic resonance imaging cellular uptake breast carcinoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/29b3c51af386470095913ed2c4468226
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spelling	oai:doaj.org-article:29b3c51af386470095913ed2c44682262021-12-02T01:10:24ZHyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy1178-2013https://doaj.org/article/29b3c51af386470095913ed2c44682262016-12-01T00:00:00Zhttps://www.dovepress.com/hyaluronan-modified-superparamagnetic-iron-oxide-nanoparticles-for-bim-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rui-Meng Yang,1,* Chao-Ping Fu,2,* Jin-Zhi Fang,1 Xiang-Dong Xu,1 Xin-Hua Wei,1 Wen-Jie Tang,1 Xin-Qing Jiang,1 Li-Ming Zhang2 1Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, 2School of Materials Science and Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, China *These authors contributed equally to this work Abstract: Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA-SPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast enhancement on T2-weighted magnetic resonance imaging and photothermal effect targeted CD44 HA receptor-overexpressing breast cancer. All these results indicated that HA-SPIONs have great potential for effective diagnosis and treatment of cancer. Keywords: iron oxide nanoparticles, surface functionalization, bioactive glycosaminoglycan, magnetic resonance imaging, cellular uptake, breast carcinomaYang RFu CFang JXu XWei XTang WJiang XZhang LDove Medical Pressarticleiron oxide nanoparticles surface functionalization bioactive glycosaminoglycan magnetic resonance imaging cellular uptake breast carcinomaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 197-206 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron oxide nanoparticles surface functionalization bioactive glycosaminoglycan magnetic resonance imaging cellular uptake breast carcinoma Medicine (General) R5-920
spellingShingle	iron oxide nanoparticles surface functionalization bioactive glycosaminoglycan magnetic resonance imaging cellular uptake breast carcinoma Medicine (General) R5-920 Yang R Fu C Fang J Xu X Wei X Tang W Jiang X Zhang L Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
description	Rui-Meng Yang,1,* Chao-Ping Fu,2,* Jin-Zhi Fang,1 Xiang-Dong Xu,1 Xin-Hua Wei,1 Wen-Jie Tang,1 Xin-Qing Jiang,1 Li-Ming Zhang2 1Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, 2School of Materials Science and Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, China *These authors contributed equally to this work Abstract: Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA-SPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast enhancement on T2-weighted magnetic resonance imaging and photothermal effect targeted CD44 HA receptor-overexpressing breast cancer. All these results indicated that HA-SPIONs have great potential for effective diagnosis and treatment of cancer. Keywords: iron oxide nanoparticles, surface functionalization, bioactive glycosaminoglycan, magnetic resonance imaging, cellular uptake, breast carcinoma
format	article
author	Yang R Fu C Fang J Xu X Wei X Tang W Jiang X Zhang L
author_facet	Yang R Fu C Fang J Xu X Wei X Tang W Jiang X Zhang L
author_sort	Yang R
title	Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
title_short	Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
title_full	Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
title_fullStr	Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
title_full_unstemmed	Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
title_sort	hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/29b3c51af386470095913ed2c4468226
work_keys_str_mv	AT yangr hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT fuc hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT fangj hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT xux hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT weix hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT tangw hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT jiangx hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy AT zhangl hyaluronanmodifiedsuperparamagneticironoxidenanoparticlesforbimodalbreastcancerimagingandphotothermaltherapy
_version_	1718403246099267584

Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy

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