Supramolecular aptamer nano-constructs for receptor-mediated targeting and light-triggered release of chemotherapeutics into cancer cells

Effective therapeutic platforms should combine serum stability, selective targeting, and controlled drug release. Here, the authors self-assemble an aptamer-based nanoscaffold that contains separate cell-targeting and photo-regulated drug-carrying domains, realizing multiple therapeutic functionalit...

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Autores principales: Deepak K. Prusty, Volker Adam, Reza M. Zadegan, Stephan Irsen, Michael Famulok
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/29b4ba7a1b2a46fe83630deece2fc4da
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Sumario:Effective therapeutic platforms should combine serum stability, selective targeting, and controlled drug release. Here, the authors self-assemble an aptamer-based nanoscaffold that contains separate cell-targeting and photo-regulated drug-carrying domains, realizing multiple therapeutic functionalities in a single construct.