Retinal oximetry using ultrahigh-resolution optical coherence tomography

Yufeng Ye,1,2 Hong Jiang,2,3 Meixiao Shen,4 Byron L Lam,2 Delia Cabrera DeBuc,2 Lili Ge,2,4 Mitra Sehi,2 Jianhua Wang21Hangzhou First People&rsquo;s Hospital, Hangzhou, China; 2Bascom Palmer Eye Institute, 3Neurology, University of Miami, Miami, FL, USA; 4School of Ophthalmology and Optometr...

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Autores principales:	Ye Y, Jiang H, Shen M, Lam BL, DeBuc DC, Ge L, Sehi M, Wang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/29ba21170ba64b90850ce95acde050ab
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spelling	oai:doaj.org-article:29ba21170ba64b90850ce95acde050ab2021-12-02T01:21:24ZRetinal oximetry using ultrahigh-resolution optical coherence tomography1177-54671177-5483https://doaj.org/article/29ba21170ba64b90850ce95acde050ab2012-12-01T00:00:00Zhttp://www.dovepress.com/retinal-oximetry-using-ultrahigh-resolution-optical-coherence-tomograp-a11728https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yufeng Ye,1,2 Hong Jiang,2,3 Meixiao Shen,4 Byron L Lam,2 Delia Cabrera DeBuc,2 Lili Ge,2,4 Mitra Sehi,2 Jianhua Wang21Hangzhou First People&rsquo;s Hospital, Hangzhou, China; 2Bascom Palmer Eye Institute, 3Neurology, University of Miami, Miami, FL, USA; 4School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, ChinaBackground: The purpose of this study was to investigate the repeatability of retinal oximetry using slit-lamp adapted ultrahigh-resolution optical coherence tomography (SL-UHR-OCT).Methods: SL-UHR-OCT was developed and fringe patterns were obtained for a major retinal artery and a major retinal vein. A-scans at the central wavelengths of 805 nm and 855 nm were analyzed for calculating optical density ratios (ODRs), from which the percentage oxygen saturation was calculated. Measurements were made on two occasions for each person. Repeatability and coefficients of repeatability were calculated.Results: The mean ODRs of the artery were 0.79 &plusmn; 0.86 and 0.88 &plusmn; 0.97 in sessions 1 and 2, respectively. The mean ODRs of the vein were &minus;0.08 &plusmn; 0.69 and 0.14 &plusmn; 0.77 between the two sessions, and were significantly lower than that of the artery (P &lt; 0.05). The coefficients of repeatability were 1.44 and 1.81 for the artery and vein, respectively. The mean oxygen saturation of the major retinal artery was 94% &plusmn; 45% and 98% &plusmn; 51% in sessions 1 and 2, respectively, and the mean oxygen saturation of the major retinal vein was 48% &plusmn; 36% and 60% &plusmn; 40% between sessions.Conclusion: Optical coherence tomographic oximetry for evaluating retinal oxygen saturation was subject to variation, although the averaged measurements in repeated sessions were matched. Further work on reducing variation will be needed.Keywords: ultrahigh-resolution optical coherence tomography, oximetryYe YJiang HShen MLam BLDeBuc DCGe LSehi MWang JDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 2085-2092 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ye Y Jiang H Shen M Lam BL DeBuc DC Ge L Sehi M Wang J Retinal oximetry using ultrahigh-resolution optical coherence tomography
description	Yufeng Ye,1,2 Hong Jiang,2,3 Meixiao Shen,4 Byron L Lam,2 Delia Cabrera DeBuc,2 Lili Ge,2,4 Mitra Sehi,2 Jianhua Wang21Hangzhou First People&rsquo;s Hospital, Hangzhou, China; 2Bascom Palmer Eye Institute, 3Neurology, University of Miami, Miami, FL, USA; 4School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, ChinaBackground: The purpose of this study was to investigate the repeatability of retinal oximetry using slit-lamp adapted ultrahigh-resolution optical coherence tomography (SL-UHR-OCT).Methods: SL-UHR-OCT was developed and fringe patterns were obtained for a major retinal artery and a major retinal vein. A-scans at the central wavelengths of 805 nm and 855 nm were analyzed for calculating optical density ratios (ODRs), from which the percentage oxygen saturation was calculated. Measurements were made on two occasions for each person. Repeatability and coefficients of repeatability were calculated.Results: The mean ODRs of the artery were 0.79 &plusmn; 0.86 and 0.88 &plusmn; 0.97 in sessions 1 and 2, respectively. The mean ODRs of the vein were &minus;0.08 &plusmn; 0.69 and 0.14 &plusmn; 0.77 between the two sessions, and were significantly lower than that of the artery (P &lt; 0.05). The coefficients of repeatability were 1.44 and 1.81 for the artery and vein, respectively. The mean oxygen saturation of the major retinal artery was 94% &plusmn; 45% and 98% &plusmn; 51% in sessions 1 and 2, respectively, and the mean oxygen saturation of the major retinal vein was 48% &plusmn; 36% and 60% &plusmn; 40% between sessions.Conclusion: Optical coherence tomographic oximetry for evaluating retinal oxygen saturation was subject to variation, although the averaged measurements in repeated sessions were matched. Further work on reducing variation will be needed.Keywords: ultrahigh-resolution optical coherence tomography, oximetry
format	article
author	Ye Y Jiang H Shen M Lam BL DeBuc DC Ge L Sehi M Wang J
author_facet	Ye Y Jiang H Shen M Lam BL DeBuc DC Ge L Sehi M Wang J
author_sort	Ye Y
title	Retinal oximetry using ultrahigh-resolution optical coherence tomography
title_short	Retinal oximetry using ultrahigh-resolution optical coherence tomography
title_full	Retinal oximetry using ultrahigh-resolution optical coherence tomography
title_fullStr	Retinal oximetry using ultrahigh-resolution optical coherence tomography
title_full_unstemmed	Retinal oximetry using ultrahigh-resolution optical coherence tomography
title_sort	retinal oximetry using ultrahigh-resolution optical coherence tomography
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/29ba21170ba64b90850ce95acde050ab
work_keys_str_mv	AT yey retinaloximetryusingultrahighresolutionopticalcoherencetomography AT jiangh retinaloximetryusingultrahighresolutionopticalcoherencetomography AT shenm retinaloximetryusingultrahighresolutionopticalcoherencetomography AT lambl retinaloximetryusingultrahighresolutionopticalcoherencetomography AT debucdc retinaloximetryusingultrahighresolutionopticalcoherencetomography AT gel retinaloximetryusingultrahighresolutionopticalcoherencetomography AT sehim retinaloximetryusingultrahighresolutionopticalcoherencetomography AT wangj retinaloximetryusingultrahighresolutionopticalcoherencetomography
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Retinal oximetry using ultrahigh-resolution optical coherence tomography

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