Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Abstract Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs...

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Autores principales: An Xie, Qiuxia Wu, Winson Fu Zun Yang, Chang Qi, Yanhui Liao, Xuyi Wang, Wei Hao, Yi-Yuan Tang, Jianbin Liu, Tieqiao Liu, Jinsong Tang
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/29ba6d0f3c324768a9a3984a388bf6b6
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spelling oai:doaj.org-article:29ba6d0f3c324768a9a3984a388bf6b62021-12-02T18:15:33ZAltered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users10.1038/s41598-021-87185-z2045-2322https://doaj.org/article/29ba6d0f3c324768a9a3984a388bf6b62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87185-zhttps://doaj.org/toc/2045-2322Abstract Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.An XieQiuxia WuWinson Fu Zun YangChang QiYanhui LiaoXuyi WangWei HaoYi-Yuan TangJianbin LiuTieqiao LiuJinsong TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
An Xie
Qiuxia Wu
Winson Fu Zun Yang
Chang Qi
Yanhui Liao
Xuyi Wang
Wei Hao
Yi-Yuan Tang
Jianbin Liu
Tieqiao Liu
Jinsong Tang
Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
description Abstract Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.
format article
author An Xie
Qiuxia Wu
Winson Fu Zun Yang
Chang Qi
Yanhui Liao
Xuyi Wang
Wei Hao
Yi-Yuan Tang
Jianbin Liu
Tieqiao Liu
Jinsong Tang
author_facet An Xie
Qiuxia Wu
Winson Fu Zun Yang
Chang Qi
Yanhui Liao
Xuyi Wang
Wei Hao
Yi-Yuan Tang
Jianbin Liu
Tieqiao Liu
Jinsong Tang
author_sort An Xie
title Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_short Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_full Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_fullStr Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_full_unstemmed Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_sort altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/29ba6d0f3c324768a9a3984a388bf6b6
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