Tablet formulation development focusing on the functional behaviour of water uptake and swelling

The functional behaviour of tablets is strongly influenced by their manufacturing process and the choice of excipients. Water uptake and swelling are prerequisites for tablet disintegration, dispersion and hence active pharmaceutical ingredient (API) dissolution. High proportions of polymeric excipi...

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Autores principales:	Jan Lenz, Jan Henrik Finke, Heike Bunjes, Arno Kwade, Michael Juhnke
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Water uptake Swelling Tablet performance Pharmaceutical polymers Amorphous solid dispersions Gelling Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/29bba37f55714ef4ad67bfa2774cadac
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spelling	oai:doaj.org-article:29bba37f55714ef4ad67bfa2774cadac2021-11-06T04:35:51ZTablet formulation development focusing on the functional behaviour of water uptake and swelling2590-156710.1016/j.ijpx.2021.100103https://doaj.org/article/29bba37f55714ef4ad67bfa2774cadac2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590156721000323https://doaj.org/toc/2590-1567The functional behaviour of tablets is strongly influenced by their manufacturing process and the choice of excipients. Water uptake and swelling are prerequisites for tablet disintegration, dispersion and hence active pharmaceutical ingredient (API) dissolution. High proportions of polymeric excipients in tablets, which are typically used as API carriers in amorphous solid dispersions (ASDs), may be challenging due to the formation of a gelling polymer network (GPN). In this study, systematic investigations into the formulation development of tablets containing polymeric and other excipients are performed by water uptake and swelling analysis. The impact of tablet composition and porosity as well as pH of the test medium are investigated. The pH affects the analysis results for Eudragit L100–55 and Eudragit EPO. HPMC and Kollidon VA64 inhibit water uptake and swelling of tablets due to the formation of a GPN. High tablet porosity, coarse particle size of the polymer and the addition of fillers and disintegrants can reduce the negative impact of a GPN on tablet performance. The application of lubricants slows down the analysed processes. Water uptake and swelling data are fitted to an empirical model obtaining four characteristic parameters to facilitate the simple quantitative assessment of varying tablet formulations and structural properties.Jan LenzJan Henrik FinkeHeike BunjesArno KwadeMichael JuhnkeElsevierarticleWater uptakeSwellingTablet performancePharmaceutical polymersAmorphous solid dispersionsGellingPharmacy and materia medicaRS1-441ENInternational Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100103- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Water uptake Swelling Tablet performance Pharmaceutical polymers Amorphous solid dispersions Gelling Pharmacy and materia medica RS1-441
spellingShingle	Water uptake Swelling Tablet performance Pharmaceutical polymers Amorphous solid dispersions Gelling Pharmacy and materia medica RS1-441 Jan Lenz Jan Henrik Finke Heike Bunjes Arno Kwade Michael Juhnke Tablet formulation development focusing on the functional behaviour of water uptake and swelling
description	The functional behaviour of tablets is strongly influenced by their manufacturing process and the choice of excipients. Water uptake and swelling are prerequisites for tablet disintegration, dispersion and hence active pharmaceutical ingredient (API) dissolution. High proportions of polymeric excipients in tablets, which are typically used as API carriers in amorphous solid dispersions (ASDs), may be challenging due to the formation of a gelling polymer network (GPN). In this study, systematic investigations into the formulation development of tablets containing polymeric and other excipients are performed by water uptake and swelling analysis. The impact of tablet composition and porosity as well as pH of the test medium are investigated. The pH affects the analysis results for Eudragit L100–55 and Eudragit EPO. HPMC and Kollidon VA64 inhibit water uptake and swelling of tablets due to the formation of a GPN. High tablet porosity, coarse particle size of the polymer and the addition of fillers and disintegrants can reduce the negative impact of a GPN on tablet performance. The application of lubricants slows down the analysed processes. Water uptake and swelling data are fitted to an empirical model obtaining four characteristic parameters to facilitate the simple quantitative assessment of varying tablet formulations and structural properties.
format	article
author	Jan Lenz Jan Henrik Finke Heike Bunjes Arno Kwade Michael Juhnke
author_facet	Jan Lenz Jan Henrik Finke Heike Bunjes Arno Kwade Michael Juhnke
author_sort	Jan Lenz
title	Tablet formulation development focusing on the functional behaviour of water uptake and swelling
title_short	Tablet formulation development focusing on the functional behaviour of water uptake and swelling
title_full	Tablet formulation development focusing on the functional behaviour of water uptake and swelling
title_fullStr	Tablet formulation development focusing on the functional behaviour of water uptake and swelling
title_full_unstemmed	Tablet formulation development focusing on the functional behaviour of water uptake and swelling
title_sort	tablet formulation development focusing on the functional behaviour of water uptake and swelling
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/29bba37f55714ef4ad67bfa2774cadac
work_keys_str_mv	AT janlenz tabletformulationdevelopmentfocusingonthefunctionalbehaviourofwateruptakeandswelling AT janhenrikfinke tabletformulationdevelopmentfocusingonthefunctionalbehaviourofwateruptakeandswelling AT heikebunjes tabletformulationdevelopmentfocusingonthefunctionalbehaviourofwateruptakeandswelling AT arnokwade tabletformulationdevelopmentfocusingonthefunctionalbehaviourofwateruptakeandswelling AT michaeljuhnke tabletformulationdevelopmentfocusingonthefunctionalbehaviourofwateruptakeandswelling
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Tablet formulation development focusing on the functional behaviour of water uptake and swelling

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