The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.

There remains much unknown about how large-scale neural networks accommodate neurological disruption, such as moderate and severe traumatic brain injury (TBI). A primary goal in this study was to examine the alterations in network topology occurring during the first year of recovery following TBI. T...

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Autores principales:	Frank G Hillary, Sarah M Rajtmajer, Cristina A Roman, John D Medaglia, Julia E Slocomb-Dluzen, Vincent D Calhoun, David C Good, Glenn R Wylie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29bf4c354600413ab82f42a41fc163cf
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spelling	oai:doaj.org-article:29bf4c354600413ab82f42a41fc163cf2021-11-25T06:04:45ZThe rich get richer: brain injury elicits hyperconnectivity in core subnetworks.1932-620310.1371/journal.pone.0104021https://doaj.org/article/29bf4c354600413ab82f42a41fc163cf2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25121760/?tool=EBIhttps://doaj.org/toc/1932-6203There remains much unknown about how large-scale neural networks accommodate neurological disruption, such as moderate and severe traumatic brain injury (TBI). A primary goal in this study was to examine the alterations in network topology occurring during the first year of recovery following TBI. To do so we examined 21 individuals with moderate and severe TBI at 3 and 6 months after resolution of posttraumatic amnesia and 15 age- and education-matched healthy adults using functional MRI and graph theoretical analyses. There were two central hypotheses in this study: 1) physical disruption results in increased functional connectivity, or hyperconnectivity, and 2) hyperconnectivity occurs in regions typically observed to be the most highly connected cortical hubs, or the "rich club". The current findings generally support the hyperconnectivity hypothesis showing that during the first year of recovery after TBI, neural networks show increased connectivity, and this change is disproportionately represented in brain regions belonging to the brain's core subnetworks. The selective increases in connectivity observed here are consistent with the preferential attachment model underlying scale-free network development. This study is the largest of its kind and provides the unique opportunity to examine how neural systems adapt to significant neurological disruption during the first year after injury.Frank G HillarySarah M RajtmajerCristina A RomanJohn D MedagliaJulia E Slocomb-DluzenVincent D CalhounDavid C GoodGlenn R WyliePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104021 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frank G Hillary Sarah M Rajtmajer Cristina A Roman John D Medaglia Julia E Slocomb-Dluzen Vincent D Calhoun David C Good Glenn R Wylie The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
description	There remains much unknown about how large-scale neural networks accommodate neurological disruption, such as moderate and severe traumatic brain injury (TBI). A primary goal in this study was to examine the alterations in network topology occurring during the first year of recovery following TBI. To do so we examined 21 individuals with moderate and severe TBI at 3 and 6 months after resolution of posttraumatic amnesia and 15 age- and education-matched healthy adults using functional MRI and graph theoretical analyses. There were two central hypotheses in this study: 1) physical disruption results in increased functional connectivity, or hyperconnectivity, and 2) hyperconnectivity occurs in regions typically observed to be the most highly connected cortical hubs, or the "rich club". The current findings generally support the hyperconnectivity hypothesis showing that during the first year of recovery after TBI, neural networks show increased connectivity, and this change is disproportionately represented in brain regions belonging to the brain's core subnetworks. The selective increases in connectivity observed here are consistent with the preferential attachment model underlying scale-free network development. This study is the largest of its kind and provides the unique opportunity to examine how neural systems adapt to significant neurological disruption during the first year after injury.
format	article
author	Frank G Hillary Sarah M Rajtmajer Cristina A Roman John D Medaglia Julia E Slocomb-Dluzen Vincent D Calhoun David C Good Glenn R Wylie
author_facet	Frank G Hillary Sarah M Rajtmajer Cristina A Roman John D Medaglia Julia E Slocomb-Dluzen Vincent D Calhoun David C Good Glenn R Wylie
author_sort	Frank G Hillary
title	The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
title_short	The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
title_full	The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
title_fullStr	The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
title_full_unstemmed	The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
title_sort	rich get richer: brain injury elicits hyperconnectivity in core subnetworks.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/29bf4c354600413ab82f42a41fc163cf
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The rich get richer: brain injury elicits hyperconnectivity in core subnetworks.

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