Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma

Background: Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, and numerous studies have demonstrated that an inflammatory environment can induce normal cells to transform into cancerous.Methods: We integrated genomic data to comprehensively assess the association between pyrop...

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Autores principales:	Zeng-Hong Wu, Zi-Wei Li, Dong-Liang Yang, Jia Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatocellular carcinoma pyroptosis lncRNAs TCGA prognosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/29bfe4ed6b394449b1118446a27d0e99
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spelling	oai:doaj.org-article:29bfe4ed6b394449b1118446a27d0e992021-11-15T05:10:54ZDevelopment and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma2296-634X10.3389/fcell.2021.713925https://doaj.org/article/29bfe4ed6b394449b1118446a27d0e992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.713925/fullhttps://doaj.org/toc/2296-634XBackground: Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, and numerous studies have demonstrated that an inflammatory environment can induce normal cells to transform into cancerous.Methods: We integrated genomic data to comprehensively assess the association between pyroptosis and tumor microenvironment (TME) cell-infiltrating characteristics in HCC, as well as the potential molecular function and clinical significance of lncRNA.Results: The analysis of CNV alteration frequency displayed that CNV changes were common in 33 PRGs, and most were focused on copy number amplification. As a result of lasso regression analysis, nine differentially expressed lncRNAs (AL031985.3, NRAV, OSMR-AS1, AC073611.1, MKLN1-AS, AL137186.2, AL049840.4, MIR4435-2HG, and AL118511.1) were selected as independent prognosis factors of HCC patients. Patients at high risk have poorer survival than those in the low-risk group in training and testing cohorts. A low-risk score was significantly associated with an IC50 of chemotherapeutics such as bortezomib (p < 0.001), but a high-risk score was significantly linked to docetaxel (p < 0.001), implying that signature served as a prospective predictor for chemosensitivity.Conclusion: This work suggests pyroptosis-related lncRNAs features and their potential mechanisms on tumor microenvironment. The exploration may assist in identifying novel biomarkers and assist patients in predicting their prognosis, clinical diagnosis, and management.Zeng-Hong WuZi-Wei LiDong-Liang YangJia LiuFrontiers Media S.A.articlehepatocellular carcinomapyroptosislncRNAsTCGAprognosisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma pyroptosis lncRNAs TCGA prognosis Biology (General) QH301-705.5
spellingShingle	hepatocellular carcinoma pyroptosis lncRNAs TCGA prognosis Biology (General) QH301-705.5 Zeng-Hong Wu Zi-Wei Li Dong-Liang Yang Jia Liu Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma
description	Background: Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, and numerous studies have demonstrated that an inflammatory environment can induce normal cells to transform into cancerous.Methods: We integrated genomic data to comprehensively assess the association between pyroptosis and tumor microenvironment (TME) cell-infiltrating characteristics in HCC, as well as the potential molecular function and clinical significance of lncRNA.Results: The analysis of CNV alteration frequency displayed that CNV changes were common in 33 PRGs, and most were focused on copy number amplification. As a result of lasso regression analysis, nine differentially expressed lncRNAs (AL031985.3, NRAV, OSMR-AS1, AC073611.1, MKLN1-AS, AL137186.2, AL049840.4, MIR4435-2HG, and AL118511.1) were selected as independent prognosis factors of HCC patients. Patients at high risk have poorer survival than those in the low-risk group in training and testing cohorts. A low-risk score was significantly associated with an IC50 of chemotherapeutics such as bortezomib (p < 0.001), but a high-risk score was significantly linked to docetaxel (p < 0.001), implying that signature served as a prospective predictor for chemosensitivity.Conclusion: This work suggests pyroptosis-related lncRNAs features and their potential mechanisms on tumor microenvironment. The exploration may assist in identifying novel biomarkers and assist patients in predicting their prognosis, clinical diagnosis, and management.
format	article
author	Zeng-Hong Wu Zi-Wei Li Dong-Liang Yang Jia Liu
author_facet	Zeng-Hong Wu Zi-Wei Li Dong-Liang Yang Jia Liu
author_sort	Zeng-Hong Wu
title	Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma
title_short	Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma
title_full	Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma
title_fullStr	Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma
title_full_unstemmed	Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma
title_sort	development and validation of a pyroptosis-related long non-coding rna signature for hepatocellular carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/29bfe4ed6b394449b1118446a27d0e99
work_keys_str_mv	AT zenghongwu developmentandvalidationofapyroptosisrelatedlongnoncodingrnasignatureforhepatocellularcarcinoma AT ziweili developmentandvalidationofapyroptosisrelatedlongnoncodingrnasignatureforhepatocellularcarcinoma AT dongliangyang developmentandvalidationofapyroptosisrelatedlongnoncodingrnasignatureforhepatocellularcarcinoma AT jialiu developmentandvalidationofapyroptosisrelatedlongnoncodingrnasignatureforhepatocellularcarcinoma
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Development and Validation of a Pyroptosis-Related Long Non-coding RNA Signature for Hepatocellular Carcinoma

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