Expression and regulation of drug transporters in vertebrate neutrophils

Abstract There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type. Here we present the...

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Autores principales:	Matthew J. Foulkes, Katherine M. Henry, Julien Rougeot, Edward Hooper-Greenhill, Catherine A. Loynes, Phil Jeffrey, Angeleen Fleming, Caroline O. Savage, Annemarie H. Meijer, Simon Jones, Stephen A. Renshaw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29c19465e7d54a27a84bf1da012fdddf
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spelling	oai:doaj.org-article:29c19465e7d54a27a84bf1da012fdddf2021-12-02T12:32:53ZExpression and regulation of drug transporters in vertebrate neutrophils10.1038/s41598-017-04785-42045-2322https://doaj.org/article/29c19465e7d54a27a84bf1da012fdddf2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04785-4https://doaj.org/toc/2045-2322Abstract There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type. Here we present the first comprehensive description and expression of both major classes of drug transporters, SLC and ABC, in resting human blood neutrophils. Moreover, we have studied the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), additionally examining the evolutionary relationship between drug transporters in zebrafish and humans. We anticipate that this will be a valuable resource to the field of inflammation biology and will be an important asset in future anti-inflammatory drug design.Matthew J. FoulkesKatherine M. HenryJulien RougeotEdward Hooper-GreenhillCatherine A. LoynesPhil JeffreyAngeleen FlemingCaroline O. SavageAnnemarie H. MeijerSimon JonesStephen A. RenshawNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew J. Foulkes Katherine M. Henry Julien Rougeot Edward Hooper-Greenhill Catherine A. Loynes Phil Jeffrey Angeleen Fleming Caroline O. Savage Annemarie H. Meijer Simon Jones Stephen A. Renshaw Expression and regulation of drug transporters in vertebrate neutrophils
description	Abstract There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type. Here we present the first comprehensive description and expression of both major classes of drug transporters, SLC and ABC, in resting human blood neutrophils. Moreover, we have studied the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), additionally examining the evolutionary relationship between drug transporters in zebrafish and humans. We anticipate that this will be a valuable resource to the field of inflammation biology and will be an important asset in future anti-inflammatory drug design.
format	article
author	Matthew J. Foulkes Katherine M. Henry Julien Rougeot Edward Hooper-Greenhill Catherine A. Loynes Phil Jeffrey Angeleen Fleming Caroline O. Savage Annemarie H. Meijer Simon Jones Stephen A. Renshaw
author_facet	Matthew J. Foulkes Katherine M. Henry Julien Rougeot Edward Hooper-Greenhill Catherine A. Loynes Phil Jeffrey Angeleen Fleming Caroline O. Savage Annemarie H. Meijer Simon Jones Stephen A. Renshaw
author_sort	Matthew J. Foulkes
title	Expression and regulation of drug transporters in vertebrate neutrophils
title_short	Expression and regulation of drug transporters in vertebrate neutrophils
title_full	Expression and regulation of drug transporters in vertebrate neutrophils
title_fullStr	Expression and regulation of drug transporters in vertebrate neutrophils
title_full_unstemmed	Expression and regulation of drug transporters in vertebrate neutrophils
title_sort	expression and regulation of drug transporters in vertebrate neutrophils
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29c19465e7d54a27a84bf1da012fdddf
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Expression and regulation of drug transporters in vertebrate neutrophils

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