Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15....

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Autores principales:	Maide Ozen, Hui Zhao, Flora Kalish, Yang Yang, Lauren L Jantzie, Ronald J Wong, David K Stevenson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29c7910acaa4428cb698e72e1631d67e
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spelling	oai:doaj.org-article:29c7910acaa4428cb698e72e1631d67e2021-12-02T20:11:02ZInflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.1932-620310.1371/journal.pone.0252642https://doaj.org/article/29c7910acaa4428cb698e72e1631d67e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252642https://doaj.org/toc/1932-6203Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1+/-) mothers, fetuses, and offspring. We show that alterations in fetal liver and spleen HO homeostasis during inflammation late in gestation can lead to a sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence [postnatal day 25] in mice.Maide OzenHui ZhaoFlora KalishYang YangLauren L JantzieRonald J WongDavid K StevensonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252642 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maide Ozen Hui Zhao Flora Kalish Yang Yang Lauren L Jantzie Ronald J Wong David K Stevenson Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
description	Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1+/-) mothers, fetuses, and offspring. We show that alterations in fetal liver and spleen HO homeostasis during inflammation late in gestation can lead to a sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence [postnatal day 25] in mice.
format	article
author	Maide Ozen Hui Zhao Flora Kalish Yang Yang Lauren L Jantzie Ronald J Wong David K Stevenson
author_facet	Maide Ozen Hui Zhao Flora Kalish Yang Yang Lauren L Jantzie Ronald J Wong David K Stevenson
author_sort	Maide Ozen
title	Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
title_short	Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
title_full	Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
title_fullStr	Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
title_full_unstemmed	Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
title_sort	inflammation-induced alterations in maternal-fetal heme oxygenase (ho) are associated with sustained innate immune cell dysregulation in mouse offspring.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/29c7910acaa4428cb698e72e1631d67e
work_keys_str_mv	AT maideozen inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring AT huizhao inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring AT florakalish inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring AT yangyang inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring AT laurenljantzie inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring AT ronaldjwong inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring AT davidkstevenson inflammationinducedalterationsinmaternalfetalhemeoxygenasehoareassociatedwithsustainedinnateimmunecelldysregulationinmouseoffspring
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Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

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